Phylogeographic Distribution of Human and Hare Francisella Tularensis Subsp. Holarctica Strains in the Netherlands and Its Pathology in European Brown Hares (Lepus Europaeus)

Frontiers in Cellular and Infection Microbiology
M G KoeneA Gröne

Abstract

Sequence-based typing of Francisella tularensis has led to insights in the evolutionary developments of tularemia. In Europe, two major basal clades of F. tularensis subsp. holarctica exist, with a distinct geographical distribution. Basal clade B.6 is primarily found in Western Europe, while basal clade B.12 occurs predominantly in the central and eastern parts of Europe. There are indications that tularemia is geographically expanding and that strains from the two clades might differ in pathogenicity, with basal clade B.6 strains being potentially more virulent than basal clade B.12. This study provides information on genotypes detected in the Netherlands during 2011-2017. Data are presented for seven autochthonous human cases and for 29 European brown hares (Lepus europaeus) with laboratory confirmed tularemia. Associated disease patterns are described for 25 European brown hares which underwent post-mortem examination. The basal clades B.6 and B.12 are present both in humans and in European brown hares in the Netherlands, with a patchy geographical distribution. For both genotypes the main pathological findings in hares associated with tularemia were severe (sub)acute necrotizing hepatitis and splenitis as well as necrotizi...Continue Reading

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Citations

Nov 30, 2019·Frontiers in Cellular and Infection Microbiology·Sandra AppeltKlaus Heuner
Feb 9, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Maëllys KevinNora Madani
Dec 10, 2020·Microorganisms·Jörg LindeHerbert Tomaso
Feb 20, 2021·Vector Borne and Zoonotic Diseases·Urška Glinšek BiškupTatjana Avšič-Županc
May 18, 2021·PLoS Neglected Tropical Diseases·Vladislav ShevtsovGilles Vergnaud

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Datasets Mentioned

BETA
PRJEB27514
ERS2585220

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

casave
CanSNPer
Illumina
ArcGIS
BBMap
SPAdes
FastQC
R

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