Physalis peruviana L. Pulp Prevents Liver Inflammation and Insulin Resistance in Skeletal Muscles of Diet-Induced Obese Mice

Nutrients
Francisco Pino-de la FuenteLuis Puente

Abstract

A chronic high-fat diet (HFD) produces obesity, leading to pathological consequences in the liver and skeletal muscle. The fat in the liver leads to accumulation of a large number of intrahepatic lipid droplets (LD), which are susceptible to oxidation. Obesity also affects skeletal muscle, increasing LD and producing insulin signaling impairment. Physalis peruviana L. (PP) (Solanaceae) is rich in peruvioses and has high antioxidant activity. We assessed the ability of PP to enhance insulin-dependent glucose uptake in skeletal muscle and the capacity to prevent both inflammation and lipoperoxidation in the liver of diet-induced obese mice. Male C57BL/6J mice were divided into groups and fed for eight weeks: control diet (C; 10% fat, 20% protein, 70% carbohydrates); C + PP (300 mg/kg/day); HFD (60% fat, 20% protein, 20% carbohydrates); and HFD + PP. Results suggest that PP reduces the intracellular lipoperoxidation level and the size of LD in both isolated hepatocytes and skeletal muscle fibers. PP also promotes insulin-dependent skeletal muscle glucose uptake. In conclusion, daily consumption of 300 mg/kg of fresh pulp of PP could be a novel strategy to prevent the hepatic lipoperoxidation and insulin resistance induced by obesity.

References

Jul 9, 2013·The Journal of Endocrinology·Mohamed Asrih, François R Jornayvaz
Aug 1, 2013·International Journal of Molecular Sciences·Alejandra EspinosaEnrique Jaimovich
Aug 22, 2013·Frontiers in Endocrinology·Sanshiro TateyaYoshikazu Tamori
May 17, 2014·International Journal of Molecular Sciences·William PeverillRichard Skoien
Sep 13, 2014·PloS One·Kimberly A NegrinMichael P Czech
Sep 30, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mohamed A DkhilAhmed E Abdel Moneim
Oct 23, 2014·Planta medica·Luis A FrancoLuis F Ospina
Mar 23, 2015·Phytochemistry·Jonathan GorelickNirit Bernstein
Apr 2, 2015·Nature Communications·Noriaki ShimizuHirotoshi Tanaka
Jun 27, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Torfay SharifniaCharles R Flynn
Mar 12, 2016·Experimental & Molecular Medicine·Hye-Sook HanSeung-Hoi Koo
May 20, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Scott M Grundy
Dec 3, 2016·The American Journal of Clinical Nutrition·Vivian L VeumGunnar Mellgren
Jan 4, 2017·The Journal of Clinical Investigation·Huaizhu Wu, Christie M Ballantyne
Sep 4, 2018·Frontiers in Chemistry·Natalia Areiza-MazoGeorge E Barreto
Nov 25, 2018·Plant Foods for Human Nutrition·Mayra S Bazalar PeredaCarmen I Viturro
Feb 12, 2019·Cellular and Molecular Gastroenterology and Hepatology·Dominic Santoleri, Paul M Titchenell
Sep 2, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Francisco Pino-de la FuenteRodrigo Troncoso

❮ Previous
Next ❯

Citations

Jul 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandra EspinosaAlicia Rodríguez
Aug 18, 2021·Food Research International·Haitao JiangWeibo Jiang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
confocal microscopy

Software Mentioned

GraphPad Prism
MXPro
FIJI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.