Physangulidines A, B, and C: three new antiproliferative withanolides from Physalis angulata L

Organic Letters
Zhuang JinGerald B Hammond

Abstract

Bioassay-directed fractionation of the whole plant of Physalis angulata L. afforded three new antiproliferative withanolides with an unusual carbon framework: physangulidines A (1), B (2), and C (3). Structures of the three isomeric withanolides were determined by a combination of HRMS, NMR spectroscopic, and X-ray crystallographic methods. Each has shown significant antiproliferative activity against DU145 prostate cancer cells. Physangulidine A (1) was further tested against a wide range of additional cancer cell lines and found to exhibit significant antiproliferative activity.

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Citations

Sep 4, 2015·Steroids·Emma MaldonadoMahinda Martínez
May 30, 2014·Natural Product Research·Huaping ZhangBarbara N Timmermann
Jun 14, 2016·Journal of Natural Products·Cheng-Peng SunFeng Qiu
May 16, 2014·Journal of the American Chemical Society·Jin-Biao XuJian-Min Yue
Jan 9, 2019·Natural Product Research·Jutatip BoonsombatSanit Thongnest
Dec 12, 2019·The Journal of Pharmacy and Pharmacology·Min HuangTao Shen
Nov 23, 2017·Organic & Biomolecular Chemistry·Gui-Yang XiaFeng Qiu
Jan 15, 2016·Chemistry & Biodiversity·Wen-Na Zhang, Wang-Yu Tong
Jul 15, 2017·World Journal of Gastroenterology : WJG·Luiz Domingues Almeida JuniorLuiz Claudio Di Stasi
May 10, 2019·Journal of Natural Products·Sebastián J CastroViviana E Nicotra
Jan 25, 2014·Journal of Natural Products·Cong-Mei CaoBarbara N Timmermann
Nov 25, 2021·Natural Product Reports·Gui-Yang XiaFeng Qiu

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