Physcion-Matured Dendritic Cells Induce the Differentiation of Th1 Cells

International Journal of Molecular Sciences
Yun-Ho HwangSung-Tae Yee

Abstract

In addition to their use as colorants, anthraquinone derivatives have numerous medical applications, for example, as antibacterial and antiinflammatory agents. We confirmed that physcion (an anthraquinone derivative) induces TNF-alpha production by macrophages and increased the expressions of surface molecules (CD40, CD80, and CD86) and major histocompatibility complex (MHC) II. Based on these results, we hypothesized that physcion might induce the maturation of dendritic cells (DCs) to antigen-presenting cells (APCs), and decided to conduct in vitro experiments using bone-marrow-derived DCs (BMDCs). Physcion was not toxic to DCs and increased the expression of surface molecules (e.g., CD40, CD80, CD86, and MHC II) and the production of cytokines (e.g., IL-12p70, IL-1beta, IL-6, and TNF-alpha), but not of IL-10. To confirm that DCs matured by physcion induce T-cell-immune responses, naive CD4+ T cells were treated with physcion-treated DCs or their supernatants. Physcion induced the maturation of DCs, which promoted the polarization of Th1 cells. Our results show physcion-induced DC maturation via TLR4, and that mature DCs promote the differentiation of Th1 cells without affecting the differentiation of Th2 cells. These finding...Continue Reading

References

Oct 1, 1993·The American Review of Respiratory Disease·P J Barnes, S Pedersen
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Oct 19, 1999·The Journal of Clinical Investigation·A Ray, L Cohn
Nov 9, 2000·Immunology Today·J RengarajanL H Glimcher
Apr 5, 2001·Trends in Immunology·T Kaisho, S Akira
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·S Suissa, P Ernst
Jul 31, 2001·The Journal of Biological Chemistry·F Re, J L Strominger
Aug 18, 2001·Cell·A Lanzavecchia, F Sallusto
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Robert A NathanTrudy B Pendergraft
Apr 29, 2004·European Journal of Immunology·Takuma KatoKagemasa Kuribayashi
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Junqing CuiSuzana Marusic
Oct 6, 2006·Medicinal Research Reviews·Qing HuangChoon Nam Ong
Jan 22, 2009·The Open Rheumatology Journal·Louise J HealyStephen J Thompson
Jun 16, 2009·Seminars in Immunology·Daphne Y Ma, Edward A Clark
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Nov 10, 2010·Nature Reviews. Immunology·Clare M Lloyd, Edith M Hessel
Feb 14, 2012·ACS Combinatorial Science·Marina Y FossoCheng-Wei Tom Chang
May 27, 2014·International Immunopharmacology·Jong-Jin KimSung-Tae Yee
Aug 16, 2017·Chinese Journal of Natural Medicines·Wei-Jun FuZhong-Qing Chen
Aug 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fei GaoHongying Chen

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Citations

Dec 8, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiao Wei JiJin Fu Wen
Jan 13, 2021·Biological & Pharmaceutical Bulletin·Maaged AkielMohammad A Alfhili

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