Physical activity and cancer risk: Findings from the UK Biobank, a large prospective cohort study.

Cancer Epidemiology
Jennifer M. MurrayRuth Hunter

Abstract

This study aimed to investigate the association between physical activity and site-specific cancer incidence. UK Biobank is a prospective population-based cohort study. 364,899 adults (51.6 % females, mean age 56.0 years) were included. The exposure variable was physical activity level derived from the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Participants were categorised at 'high' (≥1,500 MET-minutes/week), 'moderate' (≥600 MET-minutes/week) or 'low' levels of activity following standardised IPAQ-SF scoring guidance. Primary outcome measures included incident cancers at 20 sites. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) showing relationships between physical activity and cancer. 21,816 incident cancers were identified. Significant associations were identified between high physical activity levels and lower risk of lung (HR 0.81, 95 % CI: 0.70, 0.94), breast (female only) (HR 0.85, 95 % CI: 0.77, 0.94), hepatobiliary tract (HR 0.72, 95 % CI: 0.53, 0.97), and colon (HR 0.86, 95 % CI: 0.74, 0.99) cancers compared to low physical activity levels. Moderate levels of physical activity were associated with significantly lower risk of oroph...Continue Reading

References

Oct 5, 1988·Journal of the National Cancer Institute·F E HarrellB G Pollock
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jun 1, 1982·Journal of Epidemiology and Community Health·A J FoxA M Adelstein
Sep 10, 1999·International Journal of Epidemiology·I M LeeR S Paffenbarger
Sep 1, 2000·The American Journal of Clinical Nutrition·D GallagherY Sakamoto
Jul 6, 2001·Statistics in Medicine·T A StukelM R Karagas
Jul 29, 2003·American Journal of Epidemiology·M L SlatteryD Schaffer
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Apr 1, 2005·International Journal of Cancer. Journal International Du Cancer·Helle BakOle Raaschou-Nielsen
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Charles E MatthewsXiao Ou Shu
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christine FriedenreichElio Riboli
Aug 16, 2008·Cancer Causes & Control : CCC·Michael F LeitzmannChristian C Abnet
Nov 8, 2008·The International Journal of Behavioral Nutrition and Physical Activity·Stéphanie A PrinceMark Tremblay
Feb 12, 2009·British Journal of Cancer·K Y WolinI-M Lee
Mar 26, 2009·American Journal of Epidemiology·Elizabeth A StuartPhilip Leaf
Nov 13, 2009·Diabetes Care·Vojtech HainerVladimír Stich
Jan 13, 2011·Statistics in Medicine·Ian R WhiteAngela M Wood
Oct 25, 2011·The International Journal of Behavioral Nutrition and Physical Activity·Paul H LeeSunita M Stewart
Sep 5, 2012·Current Oncology Reports·Jessica Clague, Leslie Bernstein
Jan 19, 2013·Lifetime Data Analysis·Torben Martinussen, Stijn Vansteelandt
Apr 13, 2013·International Journal of Cancer. Journal International Du Cancer·Youjin JeJeffrey A Meyerhardt
Oct 8, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Janet S HildebrandAlpa V Patel
Mar 20, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D Schmid, M F Leitzmann
Apr 8, 2014·European Journal of Epidemiology·Gundula BehrensMichael Fred Leitzmann
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Mar 25, 2015·European Journal of Epidemiology·Daniela SchmidMichael Leitzmann
Jun 13, 2015·Sports Medicine·Roy J Shephard
Sep 18, 2015·Neurology·Tobias NiedermaierMichael F Leitzmann
Apr 22, 2016·International Journal of Epidemiology·Sander GreenlandNeil Pearce
Jan 7, 2017·Gynecologic Oncology·Virginia LopeUNKNOWN GEICAM, the Spanish Breast Cancer Group
Jan 22, 2017·International Journal of Cancer. Journal International Du Cancer·Kristin B BorchIdlir Licaj
Apr 21, 2017·BMJ : British Medical Journal·Carlos A Celis-MoralesJason M R Gill
Apr 23, 2017·BMC Cancer·Chen-Lin LinJeffrey S Chang
Jul 12, 2017·Annals of Internal Medicine·Tyler J VanderWeele, Peng Ding
Feb 13, 2018·Ecancermedicalscience·Peter C ElwoodZoe E Roberts
Mar 10, 2018·British Journal of Cancer·Jessica S MorrisNeil Murphy
Oct 6, 2018·United European Gastroenterology Journal·Andrew T KunzmannHelen G Coleman

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.