Physical Activity and Cerebral Small Vein Integrity in Older Adults

Medicine and Science in Sports and Exercise
C E ShaabanC Rosano

Abstract

Identifying promoters of cerebral small vein integrity is important to counter vascular contributions to cognitive impairment and dementia. In this preliminary investigation, the effects of a randomized 24-month physical activity (PA) intervention on changes in cerebral small vein integrity were compared to those of a health education (HE) control. Cerebral small vein integrity was measured in 24 older adults (n = 8, PA; n = 16, HE) using ultra-high field MRI before and at the end of the 24-month intervention. Deep medullary veins were defined as straight or tortuous; percent change in straight length, tortuous length, and tortuosity ratio were computed. Microbleed count and white matter hyperintensities were also rated. Accelerometry-based values of PA increased by 17.2% in the PA group but declined by 28.0% in the HE group. The PA group, but not the HE group, had a significant increase in straight vein length from baseline to 24-month follow-up (P = 0.02 and P = 0.21, respectively); the between-group difference in percent change in straight length was significant (increase: median, 93.6%; interquartile range, 112.9 for PA; median, 28.4%; interquartile range, 90.6 for HE; P = 0.07). Between group differences in other markers w...Continue Reading

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Citations

Jul 11, 2021·Neuroscience and Biobehavioral Reviews·Brittany IntzandtLouis Bherer

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