Physical activity and the risk of colorectal adenomas

Epidemiology
R S SandlerS I Bangdiwala

Abstract

Physical activity has repeatedly been shown to protect against colorectal cancer. Since adenomas are precursors to most colorectal cancers, we examined the relation of physical activity to the risk for colorectal adenomas in a colonoscopy-based study of 200 adenoma cases and 384 adenoma-free controls. Physical activity was assessed by telephone using a modification of a validated questionnaire comprising 17 items concerning three activity dimensions: leisure, work, and sport. Dietary information was obtained with a validated semiquantitative food frequency questionnaire. We created indices for each dimension of physical activity, which we categorized by quartile. Using logistic regression analysis, we found that leisure activity protected women against colorectal adenomas. Women in the second through fourth quartiles were considerably less likely than those in the first quartile to develop adenomas [crude odds ratio = 0.48; 95% confidence interval (CI) = 0.28-0.81]. There was no protective effect of work activity among either men or women. Men who participated in no sport were at increased risk for adenomas (odds ratio = 1.68; 95% CI = 0.93-3.02). Physical activity appears to protect against both colorectal cancer and colorecta...Continue Reading

Citations

Dec 11, 1996·International Journal of Cancer. Journal International Du Cancer·A I NeugutJ Waye
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·R TangL L Hsieh
Oct 3, 2003·Medicine and Science in Sports and Exercise·Lisa H ColbertStephen D Hursting
Mar 31, 2004·Sports Medicine·Martha L Slattery
May 27, 2003·International Journal of Cancer. Journal International Du Cancer·Yang MaoUNKNOWN Canadian Cancer Registries Epidemiology Research Group
Jul 26, 2014·Cancer Causes & Control : CCC·Christine L Sardo MolmentiElizabeth T Jacobs
Jul 24, 2002·Gastroenterology Clinics of North America·David Gatof, Dennis Ahnen
Apr 30, 2005·Nutrition and Cancer·Magda GuileraRobert S Sandler
Feb 10, 2011·British Journal of Cancer·K Y WolinG A Colditz
Dec 1, 1996·Journal of Epidemiology and Community Health·F KeeJ Moorehead
Mar 28, 2001·Annals of the New York Academy of Sciences·A Conti
Nov 8, 2002·British Medical Bulletin·Peter Boyle, Maria Elena Leon
Dec 1, 1996·Gastroenterology Clinics of North America·R S Sandler
Sep 14, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Wei-Yuan ChangHan-Mo Chiu

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