PMID: 9177588Feb 1, 1997Paper

Physical activity as a factor in the action of dietary restriction on aging: effects in Fischer 344 rats

Aging : Clinical and Experimental Research
R J McCarterC A McMahan

Abstract

Dietary restriction (DR) slows the rate of aging in laboratory rodents but the mechanism of action is unknown. DR is known to induce beneficial effects in a variety of tissues and organ systems. DR also maintains high levels of physical activity over the life span. We tested the hypothesis that lifelong physical activity is an important component of the anti-aging action of DR. Male specific pathogen-free Fischer 344 rats were divided into 4 groups at 6 weeks of age: A: fed old libitum; AE: fed ad libitum and in cages with running wheels; B: fed 60% ad libitum; BE: fed 60% ad libitum and in cages with running wheels. Running activity and spontaneous cage activity were measured over 24 hours and over the life span. Metabolic rate was measured indirectly by analysis of air entering and leaving cages. AE rats exhibited low levels of running activity and ran very little beyond 6 months of age. In contrast, BE rats sustained high running levels even after all A and AE rats had died. High levels of wheel running did not decrease spontaneous cage activity. Median life span (50% survival) was in the order A = AE < B < BE. Ten percent survival was in the order A = AE < B = BE. BE rats had greatest median life span and also highest speci...Continue Reading

References

Jun 1, 1991·Aging : Clinical and Experimental Research·E J Masoro, R J McCarter
Mar 1, 1991·Journal of Gerontology·S N Austad, K E Fischer
Apr 1, 1991·Journal of Applied Physiology·J O Holloszy, K B Schechtman
Sep 1, 1985·Journal of Applied Physiology·J O HolloszyS Adams
Nov 1, 1985·Journal of Gerontology·H MaedaB P Yu
Nov 1, 1980·Mechanisms of Ageing and Development·M SkalickyH Niedermüller
Jan 1, 1996·Free Radical Biology & Medicine·J D KimJ T Herlihy

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Citations

Feb 13, 2004·Aging Clinical and Experimental Research·Andrus Viidik, Monika Skalicky
May 17, 2012·Mechanisms of Ageing and Development·Jennifer H SternJon J Ramsey
Apr 22, 2011·Mechanisms of Ageing and Development·Kerry M CameronThomas von Zglinicki
Aug 18, 2010·Physiology & Behavior·Vesna PesicSabera Ruzdijic
Dec 24, 2015·Annals of the New York Academy of Sciences·Arlan RichardsonRoger J McCarter
May 6, 2008·Experimental Neurology·Lieselotte KirchnerGert Lubec
Jan 31, 2008·Biochimica Et Biophysica Acta·Wei-Qiang ChenGert Lubec
Jan 15, 2008·Free Radical Biology & Medicine·Emanuele MarzettiChristiaan Leeuwenburgh
Aug 26, 2003·Aging Cell·Steven N Austad, Deborah M Kristan
Jan 12, 2005·Physiology & Behavior·Helaine M AlessioRonald L Wiley
Apr 29, 2006·Ageing Research Reviews·Nicole D HuntRafael de Cabo
Oct 7, 2011·Journal of Nutrition and Metabolism·Eveliina TauriainenEero Mervaala
Jun 11, 2015·Oxidative Medicine and Cellular Longevity·Saurav Ghimire, Man Su Kim
Nov 5, 1997·Journal of the American Geriatrics Society·R A Miller
Mar 8, 2007·PLoS Medicine·Anthony E CivitareseUNKNOWN CALERIE Pennington Team
Feb 28, 2004·Brain Research·Andrea ContestabileAntonio Contestabile
Mar 1, 2005·Cell·Leonard Guarente, Frédéric Picard
Jul 14, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Aspinall
Jun 15, 2010·Experimental Aging Research·Ingeborg StelzerKonrad Schauenstein
Oct 9, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roger McCarterRandy Strong
Nov 10, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lauren B SloaneGerald E McClearn
Jan 21, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yuji IkenoJames F Nelson
May 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S CarterThomas C Foster
Jun 3, 2005·Journal of Physiological Anthropology and Applied Human Science·Hiroyasu IshiharaYoshiaki Sonoda
Mar 5, 2017·Biogerontology·Wioleta GrabowskaAnna Bielak-Zmijewska
Jan 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lisa BevilacquaMary-Ellen Harper
May 8, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alberto Diaz-RuizEvi M Mercken
Jan 1, 2000·Journal of the American Aging Association·J A MattisonA Bartke
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elinor L Sullivan, Judy L Cameron
Jun 27, 2015·EMBO Reports·Laura M ZidekCornelis F Calkhoven
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Christy S CarterChristian Leeuwenburgh
Jan 3, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S CarterSteven Austad
Jun 16, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Russell T HeppleDaniel J Krause
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Susan H McKiernanJudd Aiken

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