Physical activity attenuates genetic effects on BMI: Results from a study of Chinese adult twins

Obesity
Biqi WangLiming Li

Abstract

This study aimed to examine the gene-environment interaction of physical activity and body mass index (BMI) using the Chinese National Twin Registry (CNTR). A total of 19,308 same-sex adult twins from CNTR were included in the analysis. Twin zygosity was determined by self-reported questionnaire. Height and weight were measured using self-reported questionnaire. The vigorous physical activity was defined as greater or equal to five times a week of at least 30 min moderate- or high-intensity physical activity. A twin structural equation model was used to analyze the gene-environment interaction of vigorous exercise with BMI among 13,506 monozygotic twins and 5,802 dizygotic twins. A structural equation model adjusting for age and sex found vigorous exercise significantly moderated the additive genetic effects (P < 0.001) and shared environmental effects (P < 0.001) on BMI. The genetic contributions to BMI were significantly lower for people who adopted a physically active lifestyle [h(2) = 40%, 95% confidence interval (CI): 35%-46%] than those who were relative sedentary (h(2) = 59%, 95% CI: 52%-66%). The observed gene-physical activity interaction was more pronounced in men than women. Our results suggested that adopting a phys...Continue Reading

References

Jul 26, 2002·Briefings in Bioinformatics·Frühling V Rijsdijk, Pak C Sham
Nov 5, 2002·Nature Reviews. Genetics·Dorret BoomsmaLeena Peltonen
May 6, 2008·Nature Genetics·Ruth J F LoosKaren L Mohlke
Sep 10, 2008·Archives of Internal Medicine·Evadnie RampersaudSoren Snitker
Dec 3, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L MustelinJ Kaprio
Dec 17, 2008·Nature Genetics·Cristen J WillerUNKNOWN Genetic Investigation of ANthropometric Traits Consortium
Feb 20, 2009·The American Journal of Clinical Nutrition·Jeanne M McCafferyRena R Wing
Aug 28, 2009·The American Journal of Clinical Nutrition·Karri SilventoinenJaakko Kaprio
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Dec 24, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Fang Fang ZhangRegina M Santella
Nov 1, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B XiJ Mi
Nov 21, 2012·Nature Reviews. Endocrinology·Vasanti S MalikFrank B Hu
Jan 10, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Liming LiYonghua Hu
Sep 21, 2013·The American Journal of Clinical Nutrition·Marcel den HoedRuth J F Loos

❮ Previous
Next ❯

Citations

Mar 26, 2019·Clinical Obesity·Dennis J KerriganGwen L Alexander
Jul 5, 2019·Journal of Internal Medicine·W GaoL Li
Nov 12, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Tao HuangLiming Li
Aug 15, 2020·Laboratory animal research·Toshihiro YoshieFuminori Kawano
Aug 5, 2017·Journal of Applied Physiology·Keisuke NakamuraFuminori Kawano
Mar 20, 2021·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Yoon-Mi Hur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.