Physical activity, exercise and cardiac troponins: Clinical implications

Progress in Cardiovascular Diseases
Kristin M Aakre, T Omland

Abstract

Cardiac troponins constitute essential components of the cardiac contractile apparatus and are released into the bloodstream following cardiomyocyte injury. Because of their cardiac specificity, cardiac troponin I or T are the recommended biomarkers for diagnosing acute myocardial infarction. However, cardiac troponin concentrations also frequently increase acutely after strenuous prolonged exercise, making the interpretation of cardiac troponin test results in patients presenting with acute chest pain challenging. This acute troponin response following exercise is commonly considered to be physiological and without adverse long-term consequences, but the possibility of exercise-induced, minor myocardial injury that may become clinically relevant if repeated over decades, has not been ruled out. Attempts to biochemically differentiate between physiological cardiac troponin release versus release after acute ischemic myocardial injury has so far proved largely unsuccessful, but future measurement of specific troponin fragments could be promising. Cardiac troponins also provide strong prognostic information across the spectrum of cardiovascular (CV) disease (CVD). In the chronic setting, low-level elevation of cardiac troponins h...Continue Reading

Citations

Mar 4, 2020·Future Cardiology·Giuseppe Lippi, Fabian Sanchis-Gomar
Apr 15, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Ingrid Hov OdsæterGustav Mikkelsen
Aug 14, 2019·Circulation·Vincent L AengevaerenThijs M H Eijsvogels
Feb 18, 2020·Journal of the American Heart Association·K E Juhani Airaksinen
Dec 8, 2019·International Journal of Environmental Research and Public Health·Rafel Cirer-SastreJoaquín Reverter-Masià
Apr 2, 2020·Current Cardiology Reports·Michael C Kontos, Jeremy S Turlington
Jul 29, 2020·The Journal of Sports Medicine and Physical Fitness·Marco A PerroneAldo Clerico
Nov 5, 2020·JAMA Cardiology·Dermot PhelanEugene H Chung
Aug 28, 2021·International Journal of Environmental Research and Public Health·Marco Alfonso PerroneAttilio Parisi
Jul 6, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoMario Plebani
Feb 4, 2022·Scandinavian Journal of Clinical and Laboratory Investigation·Eli HeggenSerena Tonstad

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