Physical activity in COPD: Minimal clinically important difference for medical events

Chronic Respiratory Disease
Merilee TeylanMarilyn Moy

Abstract

Estimates of the minimal clinically important difference (MCID) for physical activity (PA) in chronic obstructive pulmonary disease (COPD) are needed. The objective is to provide an anchor-based estimate of the MCID for daily step count. PA was promoted in persons with COPD using a pedometer (Omron HJ-720ITC) alone or a pedometer plus interactive website for 3 months. Participants wore the pedometer daily and received phone calls monthly to ascertain medical events. Medical events were counted when a participant self-reported that he/she had (1) worsening of breathing, (2) change to breathing medications, (3) medical care from an emergency room for any reason, or (4) hospitalization for any reason. Generalized linear regression models assessed daily step count as change at the end of study and averaged over the 15, 31, or 61 days centered on the event, in those with an event compared to those without one. All categories of events carried equal weight in the analyses. We studied 93 persons, 46 of whom had an event. Participants who experienced an event had a decrease of 1086 (95% confidence interval (CI): -2124 to -48) or 887 (95% CI: -2030 to 257) steps/day in the pedometer plus website or pedometer alone groups, respectively, ...Continue Reading

References

Jun 1, 1992·The American Review of Respiratory Disease·P W JonesP Littlejohns
Mar 1, 1988·Chest·D A Mahler, C K Wells
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·T A SeemungalJ A Wedzicha
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Dec 8, 2004·American Journal of Respiratory and Critical Care Medicine·Gavin C DonaldsonJadwiga A Wedzicha
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Mar 16, 2006·Chest·Fabio PittaRik Gosselink
Sep 17, 2010·The New England Journal of Medicine·John R HurstUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Dec 23, 2011·Medicine and Science in Sports and Exercise·Charles E MatthewsHeather R Bowles
May 9, 2012·American Journal of Respiratory and Critical Care Medicine·Miguel DivoUNKNOWN BODE Collaborative Group
Dec 25, 2012·American Journal of Respiratory and Critical Care Medicine·Michael I PolkeyUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators
Feb 19, 2013·American Journal of Respiratory and Critical Care Medicine·Anne E Holland, Linda Nici
Apr 18, 2013·PloS One·Marilyn L MoyEric Garshick
Jan 5, 2014·American Journal of Respiratory and Critical Care Medicine·Paul W JonesJadwiga A Wedzicha
Apr 10, 2014·Annals of the American Thoracic Society·Huong Q NguyenMichael K Gould
Jun 3, 2014·BMC Pulmonary Medicine·Ayedh D AlahmariGavin C Donaldson
Aug 1, 2015·Journal of Rehabilitation Research and Development·Valery A DanilackMarilyn L Moy
Apr 29, 2016·PloS One·Heleen DemeyerThierry Troosters
Apr 30, 2016·The European Respiratory Journal·Ayedh D AlahmariGavin C Donaldson
Oct 13, 2016·ERJ Open Research·Marilyn L MoyHuong Q Nguyen

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Citations

Feb 9, 2020·International Journal of Environmental Research and Public Health·Carla SimonelliMara Paneroni
Mar 30, 2021·ERJ Open Research·Oliver PolgarClaire M Nolan
May 19, 2021·Annals of the American Thoracic Society·Anne-Marie SelzlerMichael K Stickland
Jul 17, 2021·BMC Pulmonary Medicine·Rebecca A RaphaelyMarilyn L Moy
Jul 5, 2021·Chest·Chris BurtinUNKNOWN CBQC Task Force on Physical Activity
Sep 4, 2021·ERJ Open Research·Stephanie A RobinsonMarilyn L Moy
Sep 15, 2021·Journal of Cardiopulmonary Rehabilitation and Prevention·Adnan WshahRoger Goldstein
Jan 4, 2022·Journal of Cardiopulmonary Rehabilitation and Prevention·Joice Mara de OliveiraKarina Couto Furlanetto

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Clinical Trials Mentioned

NCT01772082

Software Mentioned

SAS

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