Nov 17, 2017

Physical activity in the prevention of human diseases: role of epigenetic modifications

BMC Genomics
Elisa GrazioliDaniela Caporossi

Abstract

Epigenetic modification refers to heritable changes in gene function that cannot be explained by alterations in the DNA sequence. The current literature clearly demonstrates that the epigenetic response is highly dynamic and influenced by different biological and environmental factors such as aging, nutrient availability and physical exercise. As such, it is well accepted that physical activity and exercise can modulate gene expression through epigenetic alternations although the type and duration of exercise eliciting specific epigenetic effects that can result in health benefits and prevent chronic diseases remains to be determined. This review highlights the most significant findings from epigenetic studies involving physical activity/exercise interventions known to benefit chronic diseases such as metabolic syndrome, diabetes, cancer, cardiovascular and neurodegenerative diseases.

  • References92
  • Citations19

Citations

Mentioned in this Paper

Study
Exercise, Isometric
Chronic Disease
Nerve Degeneration
Gene Expression
Metabolic Syndrome X
Study of Epigenetics
Diabetes
Literature
Gene Function

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