Physical activity modifies genetic susceptibility to obesity in postmenopausal women

Menopause : the Journal of the North American Menopause Society
Heather M Ochs-BalcomLara E Sucheston-Campbell

Abstract

We conducted a gene-environment interaction study to evaluate whether the association of body mass index (BMI) associated meta genome-wide association study single-nucleotide polymorphisms (SNPs) (as a genetic risk score) and BMI is modified by physical activity and age. In 8,206 women of European ancestry from the Women's Health Initiative (WHI), we used linear regression to examine main effects of the 95 SNP BMI genetic risk score (GRS) and physical activity on BMI, and evaluated whether genetic associations are modified by physical activity (two-way interaction) and age (three-way interaction). We found evidence for modification of the BMI GRS-BMI association according to both physical activity and age. We observed a significant two-way interaction of BMI GRS × physical activity in the crude model (P interaction = 0.05), where a smaller effect of the BMI GRS on BMI with increasing physical activity. The beta coefficient was 0.05 (standard error [SE] = 0.02, P = 0.01) for the high-activity group compared with beta = 0.13 (SE = 0.02, P = 4.8 × 10) for the sedentary group. The three-way interaction was statistically significant (adjusted P interaction = 0.01). Notably, in the 70+ age group, the BMI GRS-BMI association was atten...Continue Reading

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Citations

May 20, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mika D ThompsonYan Yan Wu
Aug 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Carolyn J CrandallJanet Sinsheimer

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