Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder

Neural Plasticity
Cristy Phillips

Abstract

Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers.

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Citations

Aug 9, 2020·Expert Review of Neurotherapeutics·Alberto Souza Sá FilhoSergio Machado
Aug 30, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V V GultyaevaL I Aftanas
Aug 11, 2018·Frontiers in Neuroscience·Cristy Phillips, Atoossa Fahimi
Nov 24, 2020·Journal of Affective Disorders·Jer-Hwa HsuChing-Heng Lin
Dec 5, 2020·Curēus·Arohi B GandhiSafeera Khan

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Methods Mentioned

BETA
histone acetylation
acetylation

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