Physical activity modulates corticospinal excitability of the lower limb in young and old adults

Journal of Applied Physiology
Hamidollah HassanloueiSandra K Hunter

Abstract

Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is unknown. The purpose of this study was to determine the influence of age, sex, and PA on corticospinal excitability by comparing the stimulus-response curves of motor evoked potentials (MEP) in 28 young (22.4 ± 2.2 yr; 14 women and 14 men) and 50 old adults (70.2 ± 6.1 yr; 22 women and 28 men) who varied in activity levels. Transcranial magnetic stimulation was used to elicit MEPs in the active vastus lateralis muscle (10% maximal voluntary contraction) with 5% increments in stimulator intensity until the maximum MEP amplitude. Stimulus-response curves of MEP amplitudes were fit with a four-parameter sigmoidal curve and the maximal slope calculated (slopemax). Habitual PA was assessed with tri-axial accelerometry and participants categorized into either those meeting the recommended PA guidelines for optimal health benefits (>10,000 steps/day, high-PA; n = 21) or those not meeting the guidelines (<10,000 steps/day, low-PA; n = 41). The MEP amplitudes and slopemax were greater in t...Continue Reading

References

Mar 1, 1992·Clinical Science·E J BasseyL A Lipsitz
Apr 1, 1987·Journal of the American Geriatrics Society·D G MorganC E Finch
Apr 1, 1997·Experimental Brain Research·H DevanneC Capaday
Aug 1, 1997·Electroencephalography and Clinical Neurophysiology·G ZanetteA Fiaschi
Mar 10, 1999·Brain : a Journal of Neurology·M R MagistrisC W Hess
Jun 8, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S K HunterR D Adams
Feb 13, 2001·Mechanisms of Ageing and Development·G SegoviaF Mora
May 5, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B BoroojerdiL G Cohen
May 8, 2001·Exercise and Sport Sciences Reviews·T J CarrollR G Carson
Mar 19, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Stefano FacchiniSalvatore M Aglioti
Oct 17, 2002·The Journal of Physiology·Timothy J CarrollRichard G Carson
Dec 13, 2002·Experimental Brain Research·Hartwig Roman Siebner, John Rothwell
Jan 16, 2003·The Journal of Physiology·Julia B PitcherTimothy S Miles
Feb 15, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stanley J ColcombeArthur F Kramer
Jun 10, 2003·The Journal of Comparative Neurology·Lisbeth MarnerBente Pakkenberg
Aug 19, 2003·Journal of Applied Physiology·I R LanzaJ A Kent-Braun
Sep 13, 2003·Journal of Applied Physiology·Timothy J Doherty
Jan 13, 2004·Sports Medicine·Catrine Tudor-Locke, David R Bassett
Mar 16, 2004·Journal of Applied Physiology·Dario FarinaRoger M Enoka
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giampietro ZanetteStefano Tamburin
May 18, 2004·Experimental Brain Research·Young H Sohn, Mark Hallett
Apr 9, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Darren G Candow, Philip D Chilibeck
May 14, 2005·Journal of Applied Physiology·Jesper Lundbye JensenJens B Nielsen
Nov 25, 2005·Experimental Brain Research·Tibor HortobágyiJohn C Rothwell
Apr 6, 2006·Neuroscience Research·A OlivieroV Di Lazzaro
Dec 15, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stanley J ColcombeArthur F Kramer
Mar 16, 2007·Experimental Brain Research·Donna R RobertsMark S George
Nov 28, 2007·Experimental Brain Research·P TalelliN S Ward
Apr 12, 2008·Journal of Physical Activity & Health·C Tudor-LockeJ R Wojcik
Jul 19, 2008·Journal of Applied Physiology·Brian C ClarkRichard L Hoffman
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Maaike AngevarenLuc Vanhees
Jul 21, 2009·Experimental Brain Research·Ashleigh E SmithJulia B Pitcher
Oct 24, 2009·Neuroscience and Biobehavioral Reviews·Rachael D SeidlerDavid B Lipps
Nov 13, 2010·Journal of Applied Physiology·Ashleigh E SmithJulia B Pitcher
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kirk I EricksonArthur F Kramer
Mar 29, 2011·Behavioural Brain Research·Keith M McGregorBruce Crosson
May 3, 2011·Current Aging Science·Brian C Clark, Janet L Taylor
Jul 30, 2011·The International Journal of Behavioral Nutrition and Physical Activity·Catrine Tudor-LockeSteven N Blair
Oct 22, 2011·Exercise and Sport Sciences Reviews·Kieran F Reid, Roger A Fielding
Jan 13, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ryan G LarsenJane A Kent-Braun
Sep 7, 2012·Archives of Gerontology and Geriatrics·Jennifer E Stevens-LapsleyBenzi M Kluger
Nov 8, 2013·Frontiers in Aging Neuroscience·Keith M McGregorAndrew J Butler

❮ Previous
Next ❯

Citations

Mar 2, 2018·Journal of Applied Physiology·Christopher W SundbergSandra K Hunter
Nov 7, 2019·Medicine and Science in Sports and Exercise·Vianney RozandAshleigh E Smith
Apr 30, 2020·American Journal of Physiology. Cell Physiology·Laura E TeigenRobert H Fitts
Aug 14, 2020·European Journal of Applied Physiology·MinHyuk KwonSandra K Hunter
Jul 10, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Chris J McNeil, Charles L Rice
May 16, 2020·Frontiers in Aging Neuroscience·Vijay K VenkatramanPatricia M Desmond
Feb 28, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ashleigh E SmithMichael C Ridding
Jan 10, 2020·Journal of Geriatric Physical Therapy·Garrett M HesterTara M Vroman
Mar 26, 2021·The European Journal of Neuroscience·Sumiaki MaeoJonathan P Folland
May 6, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·G VarescoV Rozand
Oct 8, 2021·European Journal of Applied Physiology·Brodie J HandJohn G Semmler

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
X-ray

Software Mentioned

Spike
ActiGraph
Actilife
Systat
SPSS Statistics
Sigmaplot

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Strength and Conditioning Research
Dawson J KidgellAlan J Pearce
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Caroline MöllerUlf Ziemann
© 2022 Meta ULC. All rights reserved