Physical and physiological determinants of pulmonary venous flow: numerical analysis

The American Journal of Physiology
J D ThomasP M Vandervoort

Abstract

To study the physical and physiological determinants of transmitral and pulmonary venous flow, a lumped-parameter model of the cardiovascular system has been created, modeling the instantaneous pressure, volume, and influx/efflux of the pulmonary veins, left atrium and ventricle, systemic arteries and veins. right atrium and ventricle, and pulmonary arteries. Initial validation has been obtained by direct comparison with transesophageal echocardiographic recordings of mitral and pulmonary venous velocity for the following clinical situations: normal diastolic function, delayed ventricular relaxation, restrictive filling due to severe systolic dysfunction, severe mitral regurgitation before and after valve repair surgery, and premature atrial contraction occurring during ventricular systole. Sensitivity analysis has been performed with a Jacobian matrix, representing the proportional change in a group of output indexes (yi) in response to isolated changes in input parameters (xj), [(delta yi/yi)/ ([delta xj/xj)], demonstrating the complementary nature of mitral and pulmonary venous A-wave velocity for predicting ventricular stiffness and atrial systolic function. This unified numerical-experimental programming environment should...Continue Reading

Citations

Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M S FirstenbergM J Garcia
May 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Soren SchenkKiyotaka Fukamachi
Sep 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Zoran B PopovicJames D Thomas
Nov 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Theo ArtsFrits W Prinzen
Aug 23, 2008·Journal of Applied Physiology·David TannéPhilippe Pibarot
Mar 12, 2005·The Japanese Journal of Physiology·Eun Bo ShimChan Hyun Youn
Apr 28, 2011·Biomedical Engineering Online·Yubing ShiRodney Hose

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