Physical characterization of a new skin bioadhesive film.

AAPS PharmSciTech
A NussinovitchP Santi

Abstract

Physical properties (roughness, gloss, mechanical, surface topography and adhesive) of a bioadhesive film for the transdermal delivery of drugs and its interactions with a skin model surface were studied. Roughness is a measurement of the small-scale variations in the height of a physical surface. No significant differences in Ra between the "x" and "y" dimensions for both the skin model and patch were detected, due to uniformity in their production. Scanning electron microscope pictures showed small particles projected from the film. Those particles resulted in increasing roughness and surface area. For the patch, gloss values measured at 20 degrees were 6.0 +/- 0.9 and at 60 degrees , 32.2 +/- 2.2 gloss units, respectively, indicating a semi-gloss material. Concerning the mechanical properties, the tensile strength of the film resulted four- to sevenfold greater than the peel force from the model skin used, indicating the suitability of the film for skin application. The adhesion to skin model depended on the amount of water used for film application and on the elapsed time between film application and removal. Finally, the model skin that was invented by Charkoudian can be used as an alternative to costly and highly variable...Continue Reading

References

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Aug 28, 1998·Biomaterials·S Venkatraman, R Gale
Jan 6, 2001·Archives of Dermatological Research·K De PaepeV Rogiers
Mar 12, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina PadulaPatrizia Santi
Apr 17, 2004·Skin Pharmacology and Physiology·S NicoliP Santi
May 25, 2006·Journal of Pharmaceutical Sciences·A Femenía-FontP Santi
Jun 27, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anna M WokovichLucinda F Buhse
Jul 25, 2006·International Journal of Pharmaceutics·S NicoliP Santi
Jan 2, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cristina PadulaPatrizia Santi
Jun 2, 2007·European Journal of Dermatology : EJD·Cristina PadulaPatrizia Santi

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Citations

Apr 28, 2010·Pharmaceutical Research·Daniele Ribeiro de AraujoPatrizia Santi
Jul 14, 2010·Acta Biomaterialia·Natalie ArtziElazer R Edelman
Mar 27, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Evan M KruegerRichard I Murahata
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Yadira SalgueroMónica C García

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