Physical enrichment enhances memory function by regulating stress hormone and brain acetylcholinesterase activity in rats exposed to restraint stress

Life Sciences
Amber NawazSaida Haider

Abstract

To study the effects of stress on mental health activity is of great importance in neuropsychological studies as it may affect the lifelong performance related to brain and overall health and wellbeing of an individual. It is observed very often that exposure to stress during early life can alter the brain function which may reflect as cognitive disability. Impairment of memory is associated with increased oxidative stress which is due to enhanced production of free radicals that may lead to lipid peroxidation and disintegration of cell structure and functions. Exposure to enriched environment has shown to enhance spatial learning and memory, although the underlying mechanism covering the regulation of antioxidant capacity is limited. Here we investigated short and long term memory using Morris water maze before and after giving restraint stress procedure in rats exposed to social and physically enriched environment. Levels of malondialdehyde (MDA), activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and acetylcholinesterase (AChE) in brain tissue were estimated. Plasma corticosterone was also determined after decapitation. Results demonstrated that rats pre-exposed to physical along with socia...Continue Reading

References

May 15, 1986·Archives of Biochemistry and Biophysics·I Fridovich
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Mar 1, 1983·Developmental Psychobiology·L S Crnic
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Jan 1, 1997·International Psychogeriatrics·R C PetersenE G Tangelos
Apr 15, 1999·Biological Psychiatry·J D Bremner
Nov 11, 1999·Neurochemical Research·J Liu, A Mori
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·R A Floyd
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·E A MaguireC D Frith
Oct 18, 2000·Free Radical Biology & Medicine·E Cadenas, K J Davies
May 10, 2002·Annals of the New York Academy of Sciences·B S McEwen
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James W RussellEva L Feldman
May 30, 2003·Learning & Memory·Karyn M FrickJoanne Berger-Sweeney
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
May 1, 2004·Journal of Neuroendocrinology·F MoncekD Jezova
Nov 1, 2005·Neurobiology of Learning and Memory·Jennifer C BennettKaryn M Frick
Mar 4, 2006·Trends in Cognitive Sciences·Marian JoëlsHarm J Krugers
Aug 23, 2006·Nature Reviews. Neuroscience·Jess Nithianantharajah, Anthony J Hannan
Dec 15, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stanley J ColcombeArthur F Kramer
Oct 11, 2007·JAMA : the Journal of the American Medical Association·Sheldon CohenGregory E Miller
Nov 11, 2008·Annals of the New York Academy of Sciences·T W RobbinsB J Everitt
Jan 28, 2009·Neurochemistry International·Giancarlo LuccaJoão Quevedo
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Dec 29, 2009·Nature Neuroscience·Koji OhiraShun Nakamura
Apr 20, 2010·Molecular and Cellular Endocrinology·Agnes E Coutinho, Karen E Chapman
Aug 12, 2010·Current Pharmaceutical Design·Paula AgostinhoCatarina Oliveira
Aug 9, 2011·Behavioural Brain Research·A KorosiP J Lucassen
May 1, 2012·Trends in Cognitive Sciences·Lars NybergLars Bäckman
Sep 13, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tie Yuan ZhangMichael J Meaney

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