Physical exercise affects the epigenetic programming of rat brain and modulates the adaptive response evoked by repeated restraint stress

Behavioural Brain Research
R K KashimotoM V Gomes

Abstract

Epigenetics has recently been linked to molecular adaptive responses evoked by physical exercise and stress. Herein we evaluated the effects of physical exercise on global DNA methylation and expression of the Dnmt1 gene in the rat brain and also verified its potential to modulate responses evoked by repeated restraint stress (RRS). Wistar rats were classified into the following experimental groups: (1) physically active (EX): animals submitted to swimming during postnatal days 53-78 (PND); (2) stress (ST): animals submitted to RRS during 75-79PND; (3) exercise-stress (EX-ST): animals submitted to swimming during 53-78PND and to RRS during 75-79PND, and (4) control (CTL): animals that were not submitted to intervention. Samples from the hippocampus, cortex and hypothalamus were obtained at 79PND. The global DNA methylation profile was assessed using an ELISA-based method and the expression of Dnmt1 was evaluated by real-time PCR. Significantly increased methylation was observed in the hypothalamus of animals from the EX group in comparison to CTL. Comparative analysis involving the EX-ST and ST groups revealed increased global DNA methylation in the hippocampus, cortex, and hypothalamus of EX-ST, indicating the potential of phy...Continue Reading

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Citations

Jul 16, 2016·Behavioural Brain Research·Laura Reck CechinelIonara Rodrigues Siqueira
Oct 26, 2016·Development and Psychopathology·Audrey R TyrkaStephanie H Parade
Apr 4, 2017·Acta Physiologica·J Denham
Nov 17, 2017·BMC Genomics·Elisa GrazioliDaniela Caporossi
May 23, 2019·European Archives of Psychiatry and Clinical Neuroscience·Isabel MaurusPeter Falkai
Mar 9, 2019·CNS & Neurological Disorders Drug Targets·Ang LiKwok-Fai So
May 28, 2020·Frontiers in Aging Neuroscience·Monica A WagnerYvette P Conley
Jul 30, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuki TomigaYasuki Higaki

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