Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy

Journal of Neuroscience Research
Alexandre Aparecido de AlmeidaR M Arida

Abstract

There are a considerable number of studies concerning the behavioral effects of physical exercise on the epileptic brain; however, the intracellular signaling mechanisms involved remain unclear. We investigated the effects of aerobic exercise on hippocampal levels of brain-derived neurotrophic factor (BDNF), expression of its receptor tropomyosin receptor kinase B (TrkB), and activation of intracellular proteins related to BDNF-TrkB signaling in male Wistar rats with pilocarpine-induced epilepsy. Thirty days after the first spontaneous seizure, rats from the exercise group undertook a 30-day physical exercise program on the treadmill. Thereafter, BDNF levels, expression of TrkB, and activation of intracellular proteins were quantified by enzyme-linked immunosorbent assay, Western blotting, and multiplex assay, respectively. Statistical analyses were conducted using nonparametric tests. Rats with epilepsy presented decreased BDNF levels compared with control rats. BDNF levels increased significantly in the exercise group compared with the epileptic and control groups. Expression of full-length and truncated TrkB was increased in rats with epilepsy, and physical exercise restored its expression to control levels. RAC-alpha serine...Continue Reading

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Citations

Feb 16, 2021·Frontiers in Behavioral Neuroscience·Ricardo Mario Arida, Lavinia Teixeira-Machado
Jan 11, 2019·Neuroscience and Biobehavioral Reviews·Daniel Leite Góes GitaiAshok K Shetty
Mar 20, 2021·Epilepsy & Behavior : E&B·César Augusto HäfeleMarcelo Cozzensa da Silva
Jun 1, 2021·Hormone Molecular Biology and Clinical Investigation·Hamideh AbotalebiReyhaneh Shafieian
Jun 1, 2021·Epilepsy & Behavior : E&B·Bruno Raphael Ribeiro CavalcanteRicardo Augusto Leoni De Sousa
Aug 22, 2021·Sports Medicine·Zi-Siong ChowWei-Peng Teo
Sep 12, 2020·CNS & Neurological Disorders Drug Targets·Shareen SinghAshish Kumar Rehni
Sep 28, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ricardo Mario Arida

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