Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning.

Alzheimer Disease and Associated Disorders
Marta StojanovicDenise Head

Abstract

Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. However, the effects of exercise on longitudinal change in AD biomarkers have not been thoroughly investigated. The current study examined whether individuals with higher baseline exercise exhibited less longitudinal change in AD biomarkers and cognitive functioning, and whether APOE and/or brain-derived neurotrophic factor (BDNF) genotypes moderated the effects of exercise on longitudinal changes. Clinically normal individuals completed a questionnaire on physical exercise over the prior 10-year period at baseline. Ninety-five individuals had serial cerebrospinal fluid samples collected to examine Aβ42, ptau181 and total tau; 181 individuals underwent multiple assessments of amyloid positron emission tomography imaging with Pittsburgh Compound-B; 327 individuals underwent multiple cognitive assessments, including measures of episodic memory, executive functions, verbal fluency, and processing speed. Greater exercise was associated with less steep decline in processing speed. Baseline exercise did not robustly impact longitudinal change for any other outcomes. Neither APOE nor BDNF genotype ro...Continue Reading

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Citations

Dec 11, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Bernat de Las HerasMarc Roig
Apr 27, 2021·Journal of Alzheimer's Disease : JAD·Vince SzegeczkiTamás Juhász

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Methods Mentioned

BETA
transgenic
enzyme-linked immunosorbent assay
genotyping

Software Mentioned

R
PLINK
R nlme package

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