Physical exercise and Prader-Willi syndrome: A systematic review

Clinical Endocrinology
Javier S MoralesA Lucia

Abstract

The aim of this systematic review was to summarize evidence on the acute responses of individuals with Prader-Willi syndrome (PWS) to physical exercise, and on the effectiveness of long-term exercise interventions to improve the clinical manifestations of this syndrome. Relevant articles were identified in the electronic databases PubMed, Medline, CINAHL and SPORTDiscus (from inception to December 2018). Twenty-two studies including a total of 356 patients with PWS met all inclusion criteria and were included in the review. Patients with PWS present with a decreased physical performance and impaired cardiorespiratory (maximal oxygen consumption, heart rate recovery after exercise) and hormonal (growth hormone release) responses to exercise. Most long-term exercise interventions have proven to decrease body mass while improving physical performance. Some benefits have also been reported in biochemical (glucose homeostasis, lipid profile) and biomechanical (gait pattern) variables, although there is controversy regarding the effects on body composition. No exercise-related adverse events have been reported in patients with PWS. Physical exercise seems to be safe and effective for improving several phenotypes in PWS, notably physi...Continue Reading

References

Nov 5, 1999·JAMA : the Journal of the American Medical Association·M WeiS N Blair
May 25, 2002·Health Affairs·Kyna Rubin
Jan 10, 2003·The Journal of Pediatrics·Urs EiholzerKatrin Kromeyer-Hauschild
Mar 3, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Michael SchlumpfDagmar l'Allemand
Nov 15, 2006·American Journal of Medical Genetics. Part a·Merlin G ButlerJoseph E Donnelly
Dec 5, 2006·Pediatrics·Brian H WrotniakValerie A Kondilis
Nov 29, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F B OrtegaM Sjöström
Aug 14, 2008·The Journal of Clinical Endocrinology and Metabolism·A P GoldstoneUNKNOWN speakers contributors at the Second Expert Meeting of the Comprehensive Care of Patients with PWS
Sep 11, 2008·European Journal of Human Genetics : EJHG·Suzanne B Cassidy, Daniel J Driscoll
Apr 14, 2009·Epidemiology·Mutsumi SatoHirohito Sone
May 8, 2009·BMC Musculoskeletal Disorders·Paolo CapodaglioGraziano Grugni
Dec 17, 2009·Medicine and Science in Sports and Exercise·Jan Frystyk
Apr 17, 2010·Hormone Research in Pædiatrics·G DieneUNKNOWN French Reference Centre for PWS
Jul 30, 2010·Research in Developmental Disabilities·Luca VismaraPaolo Capodaglio
Nov 9, 2010·Neuroscience and Biobehavioral Reviews·Linda ReusMaria W G Nijhuis-van der Sanden
Dec 3, 2010·The New England Journal of Medicine·Amy Berrington de GonzalezMichael J Thun
Jan 29, 2011·Disability and Rehabilitation·Emanuele GrollaDiego Dolcetta
May 18, 2011·Journal of Neuroengineering and Rehabilitation·Paolo CapodaglioManuela Galli
Nov 29, 2011·Clinical Endocrinology·Ruth Sanchez-OrtigaNicholas A Tritos
Jan 13, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Suzanne B CassidyDaniel J Driscoll
Mar 22, 2012·Pediatric Exercise Science·Antonis KambasRenate Zimmer
Jun 2, 2012·Neuroscience and Biobehavioral Reviews·Linda ReusMaria W G Nijhuis-van der Sanden
Nov 8, 2012·Journal of Obesity·Grechi ElenaChiumello Giuseppe
Jun 14, 2013·Journal of Obesity·Diobel M CastnerAndrea M Haqq
Jul 3, 2013·Sports Medicine·Gwendolyn A ThomasJeff S Volek
Aug 22, 2013·International Journal of Pediatric Endocrinology·Jill E Emerick, Karen S Vogt
Aug 19, 2014·Research in Developmental Disabilities·Diobel M CastnerDaniela A Rubin
Dec 20, 2014·Metabolism: Clinical and Experimental·Daniela A RubinDaniel A Judelson
Jun 2, 2016·Research Quarterly for Exercise and Sport·Melanie Y LamDebra J Rose
Mar 3, 2017·Hormone Research in Pædiatrics·Daniela A RubinDaniel A Judelson
Mar 17, 2017·Eating and Weight Disorders : EWD·Itai GrossVarda Gross Tsur
Jun 24, 2017·Journal of the International Society of Sports Nutrition·Ralf JägerJose Antonio
Feb 28, 2018·Pediatric Exercise Science·Adam M HydeDaniela A Rubin
Sep 15, 2018·The Journal of International Medical Research·Wan-Ling HsuI-Shiang Tzeng
Oct 29, 2018·American Journal of Medical Genetics. Part a·Adam M HydeDaniela A Rubin
Nov 9, 2018·Medicine and Science in Sports and Exercise·Daniela A RubinDebra J Rose

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Citations

Jan 1, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Qiming TanAndrea M Haqq
Oct 4, 2019·Journal of Applied Research in Intellectual Disabilities : JARID·Alice BellichaChristine Poitou
Nov 7, 2019·American Journal of Medical Genetics. Part a·Harry J HirschNaama Constantini
Sep 15, 2020·Adolescent Health, Medicine and Therapeutics·Jennifer L Miller, Michael Tan
Jun 24, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Yuji OtoTomoyo Matsubara

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