Physical exercise and redox balance in type 2 diabetics: effects of moderate training on biomarkers of oxidative stress and DNA damage evaluated through comet assay

Oxidative Medicine and Cellular Longevity
Monica PittalugaDaniela Caporossi

Abstract

Hyperglycemia leads to increased production of reactive oxygen species (ROS) in type 2 diabetes, which reduces cellular antioxidant defenses and induces DNA lesions. The aim of this study was to investigate the effects on redox homeostasis and DNA oxidative damage of exercise training in patients with type 2 diabetes compared with nondiabetic individuals. 12 sedentary type 2 diabetic males (62.1 ± 4.3 yrs) and 12 sedentary healthy males (61.7 ± 3.9 yrs) were exposed to 4-month moderate training, 3 times per week, to evaluate the effect on plasma biomarkers of oxidative stress malondialdehyde and antioxidant status (GSSG, GSH/GSSG, and ascorbic acid) as well as basal and H2O2-induced DNA damage trough alkaline comet assay in peripheral blood lymphocytes. After training, glutathione and ascorbic acid levels increased in both groups, but only in diabetics the malondialdehyde as well as the DNA damage decreased. Our study demonstrates for the first time that moderate exercise training is not only effective in improving the redox homeostasis, through an increase of the endogenous antioxidant defences in healthy as well as in diabetic patients, but also, specifically in diabetic patients, effective in lowering the susceptibility to o...Continue Reading

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Citations

Nov 17, 2017·BMC Genomics·Elisa GrazioliDaniela Caporossi
Dec 1, 2017·Cell Stress & Chaperones·Ivan DimauroDaniela Caporossi
Jul 28, 2020·European Journal of Sport Science·Alessandra PeresGilson P Dorneles
May 24, 2017·Journal of Translational Medicine·Ning RenChen-Hao Zhou
Apr 21, 2020·Oxidative Medicine and Cellular Longevity·Márcia Fernanda Correia Jardim PazAna Amélia de Carvalho Melo Cavalcante
May 13, 2020·Neural Regeneration Research·Thais Ceresér VilelaRicardo Aurino de Pinho
Apr 26, 2017·Current Diabetes Reports·Dominik Pesta, Michael Roden
Jan 11, 2021·Journal of Hazardous Materials·Iruthayapandi Selestin RajaDong-Wook Han
Jun 29, 2021·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Rajesh G NairRamesh Mavathur
Aug 16, 2021·Journal of Bodywork and Movement Therapies·Samara Sousa Vasconcelos GouveiaLuiz Gonzaga Porto Pinheiro

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Methods Mentioned

BETA
electrophoresis
MDA
density gradient centrifugation

Software Mentioned

ChromQuest
Komet
SPSS

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