Physical exercise as an epigenetic modulator: Eustress, the "positive stress" as an effector of gene expression

Journal of Strength and Conditioning Research
Fabian Sanchis-GomarGiuseppe Lippi

Abstract

Physical exercise positively influences epigenetic mechanisms and improves health. Several issues remain unclear concerning the links between physical exercise and epigenetics. There is growing concern about the negative influence of excessive and persistent physical exercise on health. How an individual physically adapts to the prevailing environmental conditions might influence epigenetic mechanisms and modulate gene expression. In this article, we put forward the idea that physical exercise, especially long-term repetitive strenuous exercise, positively affects health, reduces the aging process, and decreases the incidence of cancer through induced stress and epigenetic mechanisms. We propose herein that stress may stimulate genetic adaptations through epigenetics that, in turn, modulate the link between the environment, human lifestyle factors, and genes.

References

Feb 1, 1993·Medicine and Science in Sports and Exercise·S SarnaJ Kaprio
May 1, 1997·The New England Journal of Medicine·I ThuneM Gaard
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Sep 13, 2006·Ageing Research Reviews·Q LuB C Richardson
Oct 13, 2006·The Journal of Biological Chemistry·Clay E PandorfKenneth M Baldwin
Apr 20, 2007·Cancer Treatment Reviews·Giuseppe LippiGian Cesare Guidi
Jun 15, 2007·Trends in Genetics : TIG·Mario F Fraga, Manel Esteller
Jul 20, 2007·Nature·Ander MatheuManuel Serrano
Aug 19, 2007·Nature Reviews. Molecular Cell Biology·Philipp Oberdoerffer, David A Sinclair
Jun 3, 2008·Journal of Molecular Endocrinology·Kjersti M Aagaard-TilleryRobert H Lane
Nov 4, 2009·The Journal of Physiology·Sean L McGeeMark Hargreaves
Dec 17, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Eusebio PerdigueroPura Muñoz-Cánoves
May 4, 2010·World Review of Nutrition and Dietetics·Emily Ho, Roderick H Dashwood
Sep 16, 2010·Annals of the New York Academy of Sciences·Neoklis A GeorgopoulosKostas B Markou
Sep 30, 2010·British Journal of Sports Medicine·Jonatan R RuizAlejandro Lucia
Oct 30, 2010·Journal of Applied Physiology·Sean L McGee, Mark Hargreaves
Dec 24, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Fang Fang ZhangRegina M Santella
May 25, 2011·Muscle & Nerve·Jeff R S LeiterJudy E Anderson
Jun 1, 2011·Ageing Research Reviews·Perla KalimanMercè Pallàs
Jun 4, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Christopher Faulk, Dana C Dolinoy
Jun 15, 2011·Drug Testing and Analysis·Heidi Schwarzenbach
Jul 19, 2011·Nature Reviews. Genetics·Anne C Ferguson-Smith
Nov 30, 2011·Epigenomics·Jorge Alejandro Alegría-TorresValentina Bollati
Jan 5, 2012·Nature Reviews. Genetics·Robert Feil, Mario F Fraga

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Citations

Jan 4, 2013·Biogerontology·Moisés E BauerJos A Bosch
Jan 9, 2014·Sports Medicine·Helios Pareja-GaleanoJosé Luis García-Giménez
Oct 29, 2013·Sports Medicine·Joshua DenhamFadi J Charchar
May 9, 2013·Climacteric : the Journal of the International Menopause Society·P Chedraui, F R Pérez-López
Jul 16, 2013·Nursing Outlook·Michelle L WrightCindy M Anderson
Oct 28, 2014·Acta Physiologica·S VoisinD J Bishop
Oct 21, 2015·Metabolism: Clinical and Experimental·Júlia Matzenbacher Dos SantosSandra Aparecida Benite-Ribeiro
Jul 7, 2015·Scandinavian Journal of Medicine & Science in Sports·C G M SantosR Silva
Feb 12, 2015·Clinical Science·Smriti Murali KrishnaJonathan Golledge
Mar 20, 2015·Frontiers in Psychology·Daniel ThomsonLouisa Sylvia
Nov 29, 2014·Rejuvenation Research·Nuria GaratacheaAlejandro Lucia
Nov 5, 2014·Frontiers in Cell and Developmental Biology·Riya R KanherkarAntonei B Csoka
Jul 5, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe LippiFederico Schena
Mar 28, 2018·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Maarten CaspersMartine Thomis
Nov 17, 2017·BMC Genomics·Elisa GrazioliDaniela Caporossi
Aug 26, 2018·Biotechnology and Applied Biochemistry·Sadegh RezapourMahnaz Mardani
May 16, 2017·Current Behavioral Neuroscience Reports·C M HearingL G Sylvia
Jun 12, 2018·Frontiers in Endocrinology·Alexandre Rebelo-MarquesJoão Espregueira-Mendes
Jan 11, 2019·Dose-response : a Publication of International Hormesis Society·Jonathan StoneJanis Eells
Jul 14, 2020·SAGE Open Medicine·Fabrício Boscolo Del VecchioPaulo Gentil
Apr 20, 2020·Journal of the Neurological Sciences·Sabrina SwensonPanayotis K Thanos
May 4, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Débora da Luz Scheffer, Alexandra Latini
Jun 1, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Anna MukhaSaskia W C van Mil
Jul 23, 2021·Scientific Reports·Kuniaki OtsukaChiaki Mukai

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