Physical exercise contributes to cisplatin-induced nephrotoxicity protection with decreased CD4+ T cells activation

Molecular Immunology
Mariana Yasue Saito MiyagiMariane T Amano

Abstract

Cisplatin is a chemotherapy used to treat different types of cancer, such as testicular, bladder and head and neck. Physical exercise has been shown to improve cancer therapy and recently, it was demonstrated to be able to diminish side effects such as acute kidney injury (AKI), a common side effect in cisplatin treatment. In both cases, the modulation of inflammatory cytokines seems to be one of the mechanisms, but little is known about the immune cells in this process. Here, we investigated the role of CD4 + T cells in the AKI protection by physical exercise. We subjected C57Bl6 mice to long-term physical exercise (EX) before cisplatin treatment. Sedentary groups were used as control (CT). We confirmed that physical exercise decreased AKI by evaluating creatinine and Kim-1 levels, in the serum and kidney respectively. Analyzing the organs weight, we noticed a decrease in sedentary (CIS) and exercised (CIS-EX) cisplatin treated groups. Epididymal and brown adipose tissue weight were decreased in cisplatin treated subjects in comparison to untreated groups, as well as liver and spleen. We then investigated the profile of CD4 + T cells in the spleen and we observed increased levels of Tregs and CD4+CD25+ cells in CIS group, whil...Continue Reading

Citations

Oct 30, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Songling JiangHunjoo Ha
Dec 8, 2020·BioMed Research International·Sheila M F CoutoMaria De Fátima F Vattimo
Feb 5, 2021·International Journal of Environmental Research and Public Health·Kuan-Yin LinKun-Ling Tsai

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