Physical Exercise for Treatment of Mood Disorders: A Critical Review

Current Behavioral Neuroscience Reports
C M HearingLouisa G Sylvia

Abstract

The purpose of this review is to critically assess the evidence for exercise as an adjunct intervention for major depressive disorder and bipolar disorder, chronic conditions characterized by frequent comorbid conditions as well as interepisodic symptoms with poor quality of life and impaired functioning. Individuals with these mood disorders are at higher risk of cardiovascular disease and premature death in part because of increased rates of obesity, inactivity, and diabetes mellitus compared to the general population. Exercise may not only mitigate the increased risk of cardiovascular disease, but could also potentially improve the long term outcomes of mood disorders. We conducted a literature review on the impact of exercise on mood disorders and associated comorbid conditions as well as possible biological mechanisms. We found that exercise impacts both the physical health parameters of mood disorders as well as mental health outcomes. Exercise also positively impacts conditions frequently comorbid with mood disorders (i.e. anxiety, pain, and insomnia). There are multiple candidate biomarkers for exercise, with brain-derived neurotrophic factor and oxidative stress as two main promising components of exercise's anti-depre...Continue Reading

Associated Clinical Trials

Apr 15, 2020·Joanna Szczepańska-Gieracha

References

Jul 1, 1991·Postgraduate Medicine·D J Mersy
Apr 1, 1986·The American Journal of Psychiatry·W CoryellJ D House
Mar 1, 1995·Pharmacopsychiatry·T BaptistaL Hernàndez
Jun 1, 1996·The Psychiatric Clinics of North America·M Fava, K G Davidson
May 20, 1998·The American Journal of Psychiatry·A BroocksE Rüther
Mar 31, 2000·Comprehensive Psychiatry·M FavaJ F Rosenbaum
Jan 4, 2001·Trends in Neurosciences·A F Schinder, M Poo
Jul 24, 2001·The Journal of Clinical Psychiatry·J L ElmslieS E Romans
Apr 3, 2002·The Journal of Clinical Psychiatry·Mark ZimmermanWilson McDermut
Jun 25, 2003·Toxicology·Maria L Urso, Priscilla M Clarkson
Nov 12, 2003·Archives of Internal Medicine·Matthew J BairKurt Kroenke
Mar 3, 2004·Archives of General Psychiatry·Christine KonradiStephan Heckers
Mar 12, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Robert M. A. Hirschfeld
Apr 13, 2004·International Clinical Psychopharmacology·M Erkan OzcanOmer Akyol
Jun 17, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Richard J Bloomer, Allen H Goldfarb
Nov 3, 2004·Growth Factors·Devin K Binder, Helen E Scharfman
Nov 10, 2004·Genomics·Kae MunakataTadafumi Kato
Jan 1, 2005·American Journal of Preventive Medicine·Andrea L DunnHeather O Chambliss
Jun 3, 2005·The American Journal of Psychiatry·Mark Hyman RapaportJean Endicott
Aug 15, 2006·Clinical Psychology Review·Louisa D GrandinLyn Y Abramson
Dec 19, 2006·Journal of Affective Disorders·Bun-Hee LeeYong-Ku Kim
Dec 22, 2006·Journal of Affective Disorders·Felicity NgMichael Berk
Jan 24, 2007·Biological Psychiatry·Carrie E BeardenJair C Soares
Feb 17, 2007·Journal of Applied Physiology·Michael Gleeson
Mar 14, 2007·International Review of Neurobiology·Olivier GuillinFlorence Thibaut
May 9, 2007·Archives of General Psychiatry·Kathleen R MerikangasRonald C Kessler
May 25, 2007·Nature·Adrian Bird
Jun 21, 2007·Psychological Medicine·Andreas StröhleRoselind Lieb
Aug 8, 2007·Bipolar Disorders·Amy M KilbourneFrederic C Blow
Aug 10, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie E BeardenJair C Soares
Sep 4, 2007·Trends in Neurosciences·Carl W CotmanLori-Ann Christie
Sep 12, 2007·Psychosomatic Medicine·James A BlumenthalAndrew Sherwood
Jan 12, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jun-Feng Wang
Jan 22, 2008·The International Journal of Neuropsychopharmacology·Felicity NgAshley I Bush
Jan 29, 2008·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Mauro Giovanni CartaMassimiliano Salvi

❮ Previous
Next ❯

Citations

Dec 12, 2017·Genes, Brain, and Behavior·Danielle M DickJinni Su
Feb 7, 2018·Current Addiction Reports·Wendy J LynchMark A Smith
Oct 6, 2017·Journal of Occupational Rehabilitation·Haitze de VriesUta Wegewitz
Oct 20, 2018·Chronobiology International·Małgorzata SławińskaKonrad S Jankowski
Jan 11, 2020·Borderline Personality Disorder and Emotion Dysregulation·Aylin MehrenAlexandra Philipsen
Nov 11, 2018·International Journal of Environmental Research and Public Health·Vera SchellewaldRolf Ellegast
Apr 4, 2019·Trends in psychiatry and psychotherapy·Caroline Silveira PereiraPedro V S Magalhães
Oct 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V V GultyaevaL I Aftanas
Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
May 8, 2020·Journal of Medical Internet Research·Anthoula C TsolakiPanagiotis D Bamidis
Dec 24, 2018·Frontiers in Behavioral Neuroscience·Anke Hoffmann, Dietmar Spengler
Dec 15, 2020·Frontiers in Psychology·Peter C TerryVictoria R Terry
Apr 20, 2020·Journal of the Neurological Sciences·Sabrina SwensonPanayotis K Thanos
Jun 2, 2020·Journal of Affective Disorders·Laura HollandsColin Greaves
Apr 18, 2019·Trends in psychiatry and psychotherapy·Caroline Silveira PereiraPedro V S Magalhães
May 18, 2019·Disability and Health Journal·Aaron P TurnerJodie K Haselkorn
Apr 20, 2021·Work : a Journal of Prevention, Assessment, and Rehabilitation·Petros GalanisTheodoros A Katsoulas
May 1, 2021·Behavioral Sciences·Parisa Gazerani
May 6, 2021·Journal of Sports Science & Medicine·Paulina MorgaJoanna Szczepańska-Gieracha
Aug 28, 2021·Clinics and Practice·Yolanda Morcillo-MuñozMaria Isabel Baena-Parejo
Aug 31, 2021·Frontiers in Physiology·Yucong Wang, Kalaiselvan Ashokan
Aug 30, 2021·Mayo Clinic Proceedings·Lucinda BatemanBrayden P Yellman
May 8, 2018·Explore : the Journal of Science and Healing·Heather TickUNKNOWN Pain Task Force of the Academic Consortium for Integrative Medicine and Health

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