Physical Exercise May Increase Plasma Concentration of High-Density Lipoprotein-Cholesterol in Patients With Alzheimer's Disease

Frontiers in Neuroscience
Camilla Steen JensenAnja Hviid Simonsen

Abstract

Lifestyle factors have been shown to increase the risk of developing Alzheimer's disease (AD) later in life. Specifically, an unfavorable cholesterol profile, and insulin resistance are associated with increased risk of developing AD. One way to non-pharmacologically affect the levels of plasma lipids is by exercise, which has been shown to be beneficial in cognitively healthy individuals. In this randomized controlled trial y, we therefore aimed to clarify the effect of physical exercise on the lipid profile, insulin and glucose in patients with AD. In addition, we investigated the effect of apolipoproteinE genotype on total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglycerides (TG) in plasma from patients with AD. Plasma samples from 172 patients who underwent 16 weeks of moderate-to-high intensity exercise (n = 90) or treatment as usual (n = 82) were analyzed change from baseline for the levels of total cholesterol, LDL-C, HDL-C, TG, glucose, and insulin. In addition, we analyzed those from the exercise group who adhered to the protocol with an attendance of 2/3 or more of the exercise session and who followed the protocol of an intensity of 70% of the maxim...Continue Reading

References

Mar 1, 1992·The American Journal of Clinical Nutrition·P J GarryB J Vellas
Feb 19, 2000·The American Journal of Clinical Nutrition·E T Poehlman, R V Dvorak
Jul 11, 2000·Nature Medicine·B V ZlokovicB Frangione
Jul 11, 2000·Nature Medicine·B V ZlokovicB Frangione
Nov 10, 2001·Annual Review of Genomics and Human Genetics·R W Mahley, S C Rall
Nov 5, 2002·Annual Review of Public Health·Sandra K PopeCornelia Beck
Jan 11, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Werner KochAdnan Kastrati
Oct 19, 2005·Preventive Cardiology·George A KelleyZung V Tran
Dec 20, 2005·Lancet Neurology·Geert Jan BiesselsPhilip Scheltens
Jan 18, 2006·Brain Research Reviews·Francesco PanzaVincenzo Solfrizzi
Mar 1, 2008·British Journal of Sports Medicine·J G Z van UffelenM Hopman-Rock
Jan 13, 2010·Archives of Neurology·Laura D BakerSuzanne Craft
Feb 5, 2010·Dementia and Geriatric Cognitive Disorders·Ramit Ravona-SpringerMichal Schnaider Beeri
Feb 26, 2011·Lancet Neurology·Philip B VergheseDavid M Holtzman
Mar 31, 2011·Nature Reviews. Neuroscience·Gilbert Di Paolo, Tae-Wan Kim
Jan 7, 2014·Clinical Biochemistry·Charlotte E TeunissenBrit Mollenhauer
Nov 11, 2014·Journal of the International Neuropsychological Society : JINS·Georgina E CrichtonMichael A Robbins
Nov 22, 2014·Diabetes·Sarah M GrayEugene J Barrett
Dec 4, 2014·Annals of Neurology·Katrine L RasmussenRuth Frikke-Schmidt
Dec 20, 2015·Journal of Alzheimer's Disease : JAD·Kristine HoffmannSteen G Hasselbalch
Apr 27, 2016·The International Journal of Neuroscience·Kristyn A BatesRalph N Martins
Apr 28, 2016·JAMA Internal Medicine·Samia Mora
Jun 28, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nanna Aue SobolNina Beyer
Dec 7, 2016·Current Opinion in Lipidology·Fan LiaoJungsu Kim
Jul 7, 2017·Lipids in Health and Disease·Yating Wang, Danyan Xu
Apr 5, 2019·Current Opinion in Lipidology·Emily B ButtonCheryl L Wellington
Apr 24, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Camilla Steen JensenSteen Gregers Hasselbalch

❮ Previous
Next ❯

Citations

Jan 19, 2021·Curēus·Mehak Agarwal, Safeera Khan

❮ Previous
Next ❯

Methods Mentioned

BETA
Genotyping

Software Mentioned

SPSS Statistics
MATLAB

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.