Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide-induced sepsis in rats

Journal of Cellular Biochemistry
Vanessa Valéria MironAndréia Machado Cardoso

Abstract

Sepsis is a generalized infection that involves alterations in inflammatory parameters, oxidant status, and purinergic signaling in many tissues. Physical exercise has emerged as a tool to prevent this disease because of its anti-inflammatory and antioxidant properties. Thus, in this study, we investigated the effects of physical exercise on preventing alterations in purinergic system components, oxidative stress, and inflammatory parameters in lipopolysaccharide (LPS)-induced sepsis in rats. Male Wistar rats were divided into four groups: control, exercise (EX), LPS, and EX+LPS. The resisted physical exercise was performed for 12 weeks on a ladder with 1 m height. After 72 hours of the last exercise session, the animals received 2.5 mg/kg of LPS for induction of sepsis, and after 24 hours, lungs and blood samples were collected for analysis. The results showed that the exercise protocol used was able to prevent, in septic animals: (1) the increase in body temperature; (2) the increase of lipid peroxidation and reactive species levels in the lung, (3) the increase in adenosine triphosphate levels in serum; (4) the change in the activity of the enzymes ectonucleotidases in lymphocytes, partially; (5) the change in the density of...Continue Reading

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Citations

Feb 4, 2021·Journal of Immunology Research·Charles Elias AssmannVera Maria Melchiors Morsch
Feb 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Karine Paula ReichertMaria Rosa Chitolina Schetinger
Oct 1, 2021·Purinergic Signalling·Andréia Machado CardosoSarah Franco Vieira de Oliveira Maciel

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