Physical exercise prevents cognitive impairment by enhancing hippocampal neuroplasticity and mitochondrial function in doxorubicin-induced chemobrain

Neuropharmacology
Hye-Sang ParkTae-Woon Kim

Abstract

Although chemotherapy increases the survival rate of patients with various cancers, such treatment can induce acute or long-term cognitive dysfunction a phenomenon known as post-chemotherapy cognitive impairment (PCCI) or "chemobrain." Exercise is known to positively affect brain function. Thus, the present study aimed to determine whether symptoms of chemobrain and disruptions in the neuroplasticity and functioning of hippocampal mitochondria can be prevented or relieved by exercise. Wistar rats were separated into the following groups: control, control plus exercise, chemobrain, and chemobrain plus exercise. For chemobrain induction, 2 mg/kg of doxorubicin (DOX) a widely utilized chemotherapeutic agent among patients with breast cancer was dissolved in saline and directly injected to the abdomen once every 4 weeks. The exercise groups were subjected to low-intensity treadmill, 6 days per week for 4 weeks. The Morris water maze and step-down avoidance tests were conducted to evaluate cognitive function, while neuroplasticity and mitochondrial function were assessed in the hippocampus and dentate gyrus. Decreased cognitive function were observed in the chemobrain group, along with decreases in levels of neurogenesis, brain deri...Continue Reading

Citations

Aug 27, 2019·Current Opinion in Oncology·Erin M Gibson, Michelle Monje
Sep 5, 2019·Current Opinion in Oncology·Marijke B CoomansMartin J B Taphoorn
Jan 5, 2020·Neurotoxicity Research·Ashley HenneghanShelli R Kesler
Apr 29, 2020·Veterinary Medicine and Science·Ahmed SalmanSalma Salman
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Feb 6, 2020·Experimental and Therapeutic Medicine·Dehua LiaoPei Jiang
Oct 22, 2020·The International Journal of Neuroscience·Na JiaLina Sun
Jan 19, 2021·Life Sciences·Fatma H ShakerHala O El-Mesallamy
Jan 9, 2021·Neural Plasticity·Matheus Santos de Sousa FernandesTony Meireles Santos
Mar 7, 2021·Trends in Neurosciences·Erin M Gibson, Michelle Monje
Jun 1, 2021·Frontiers in Oncology·Jiajia DuHongyan Jia
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