Physical Exercise Training versus Relaxation in Allogeneic stem cell transplantation (PETRA Study) - Rationale and design of a randomized trial to evaluate a yearlong exercise intervention on overall survival and side-effects after allogeneic stem cell transplantation

BMC Cancer
Joachim WiskemannMartin Bohus

Abstract

Allogeneic stem cell transplantation (allo-HCT) is associated with high treatment-related mortality and innumerable physical and psychosocial complications and side-effects, such as high fatigue levels, loss of physical performance, infections, graft-versus-host disease (GvHD) and distress. This leads to a reduced quality of life, not only during and after transplantation, but also in the long term. Exercise interventions have been shown to be beneficial in allo-HCT patients. However, to date, no study has focused on long-term effects and survival. Previous exercise studies used 'usual care' control groups, leaving it unclear to what extent the observed effects are based on the physical effects of exercise itself, or rather on psychosocial factors such as personal attention. Furthermore, effects of exercise on and severity of GvHD have not been examined so far. We therefore aim to investigate the effects and biological mechanisms of exercise on side-effects, complications and survival in allo-HCT patients during and after transplantation. The PETRA study is a randomized, controlled intervention trial investigating the effects of a yearlong partly supervised mixed exercise intervention (endurance and resistance exercises, 3-5 ti...Continue Reading

References

Apr 24, 1975·The New England Journal of Medicine·E D ThomasC D Buckner
Jan 1, 1978·Health Education Monographs·K A WallstonR DeVellis
Jul 1, 1991·The American Journal of Clinical Nutrition·K R SegalJ Wang
Aug 1, 1973·Journal of Abnormal Psychology·T D Borkovec, D C Fowles
Apr 1, 1995·Journal of Psychosomatic Research·E M SmetsJ C De Haes
Jan 1, 1997·Archives of Physical Medicine and Rehabilitation·R W Bohannon
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·P L Enright, D L Sherrill
Apr 6, 1999·The Journal of Experimental Medicine·D ZengS Strober
Jun 17, 2000·Archives of Physical Medicine and Rehabilitation·Y M NaD S Yoon
May 3, 2001·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M J SchroeversA V Ranchor
Jul 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Schwarz, A Hinz
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Nov 14, 2002·The Medical Journal of Australia·Elaine M BellerAnthony C Keech
May 29, 2003·Onkologie·R SchwarzA Hinz
Oct 1, 1955·Journal of Consulting Psychology·R M REITAN
Sep 26, 2003·European Journal of Applied Physiology·Joshua M DrouinDavid H Perrin
Apr 3, 2004·British Journal of Haematology·Dong Hwan KimKyu Bo Lee
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A AndrykowskiJohn R Wingard
Mar 18, 2005·Journal of Applied Physiology·Anne Marie W Petersen, Bente Klarlund Pedersen
Jun 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruud KnolsGeert Aufdemkampe
Oct 7, 2005·Psycho-oncology·Sean RansomMargaret Booth-Jones
Apr 28, 2006·The New England Journal of Medicine·Edward A Copelan
May 6, 2006·Oncology Nursing Forum·Eileen Hacker DanaherNatalie Dieterle
Nov 4, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G VelikovaUNKNOWN EORTC Quality of Life Group
Aug 1, 2007·The Oncologist·Julie L RyanGary R Morrow
Mar 7, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Margaret F BevansSusan Marden
Dec 31, 2008·Biological Research for Nursing·Sadeeka Al-Majid, D Patricia Gray
Jan 14, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Keith M BellizziNoreen M Aziz
Feb 11, 2009·Medicine and Science in Sports and Exercise·UNKNOWN American College of Sports Medicine
Mar 14, 2009·Lancet·James L M FerraraErnst Holler
May 1, 2009·Journal of the International Neuropsychological Society : JINS·I Sánchez-CubilloF Barceló

❮ Previous
Next ❯

Citations

May 18, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rea KuehlJoachim Wiskemann
Jun 29, 2017·Medicine and Science in Sports and Exercise·Joachim WiskemannMartin Bohus
Feb 1, 2019·The Cochrane Database of Systematic Reviews·Linus KnipsNicole Skoetz
Aug 8, 2017·Bone Marrow Transplantation·J MohammedS K Hashmi
Oct 19, 2019·Medicine and Science in Sports and Exercise·Alpa V PatelCharles E Matthews

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT01374399

Software Mentioned

PETRA
OnkoActive

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here