Physical exertion as a trigger of acute coronary syndrome caused by plaque erosion.

Journal of Thrombosis and Thrombolysis
Ayami KatoJunya Ako

Abstract

Distinct clinical characteristics have been demonstrated in patients with plaque erosion as compared with those with plaque rupture. We reasoned that greater physical activity might influence the onset of plaque erosion. In total, 97 consecutive patients with non ST-segment elevation acute coronary syndrome (ACS) who underwent optical coherence tomography (OCT) imaging of the culprit lesion were enrolled. OCT-determined culprit plaque characteristics were plaque erosion (18.6%), calcified plaque (26.8%), plaque rupture (32.0%) and other (22.7%). The physical activity evaluated by estimated metabolic equivalents (METs) at ACS onset was significantly greater in the plaque erosion group than in the plaque rupture group (3.3 ± 1.7 vs. 2.1 ± 1.0, p = 0.011). The rate of ACS onset outdoors was the highest (61.1%) in the plaque erosion group. The combination of greater physical activity (> 3 METs), outdoor onset and higher body mass index (> 25.1 kg/m2) had a significant odds ratio for the incidence of plaque erosion (odds ratio 15.0, 95% confidence interval 3.81 to 59.0, p < 0.001). Plaque erosion was associated with greater physical activity at the onset. This finding may help to further clarify the pathogenesis of ACS Impact of phy...Continue Reading

References

Aug 1, 1994·Thrombosis Research·J L ChicharroJ C Legido
Nov 24, 1999·JAMA : the Journal of the American Medical Association·S GiriD D Waters
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Frank D KolodgieRenu Virmani
Mar 23, 2006·JAMA : the Journal of the American Medical Association·William WhangChristine M Albert
Jun 7, 2008·European Heart Journal·Stephanie von KlotAnnette Peters
Aug 5, 2011·International Journal of Biological Sciences·Jingmei DongWeihua Xiao
Dec 18, 2012·European Heart Journal·Erling FalkRenu Virmani
Dec 31, 2014·European Heart Journal·Peter Libby
Oct 27, 2015·Molecular Medicine Reports·Ya-Jun ZhuLing Li
Nov 12, 2015·BioMed Research International·Stefan Heber, Ivo Volf
Jul 7, 2017·Current Opinion in Lipidology·Thibaut QuillardPeter Libby
Dec 13, 2017·The American Journal of Cardiology·Barry A FranklinLaurence S Sperling
Jun 23, 2018·Circulation Research·Oliver SoehnleinMarit Westerterp
Jan 4, 2019·Circulation Research·Peter LibbyIk-Kyung Jang
Mar 23, 2019·JACC. Cardiovascular Interventions·Tomoyo SugiyamaIk-Kyung Jang

❮ Previous
Next ❯

Citations

Aug 11, 2020·Journal of Interventional Cardiology·Caterina Mas-LladóVicente Peral-Disdier
Feb 19, 2021·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·E R de KoningS L M A Beeres
May 5, 2020·Archives of Cardiovascular Diseases·Fabien HuetFrançois Roubille

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.