Physical exposures during pregnancy and congenital cardiovascular malformations

Paediatric and Perinatal Epidemiology
Christine M JudgeElizabeth G Marshall

Abstract

Congenital cardiovascular malformations (CCM) cause substantial neonatal morbidity and mortality. Known risk factors for CCM explain only 10-20% of all cases. Few studies have examined mothers' physical exposures during pregnancy and the risk of CCM in their offspring. This study examined the association between exposures to extreme temperatures, prolonged standing, and heavy lifting during early pregnancy and risk of CCM in offspring. Using a case-control study design, 502 cases and 1066 controls were drawn from the population of all liveborn infants born between January 1988 and June 1991 to mothers living in 14 counties in New York State. Cases were identified from a population-based registry of congenital malformations. Controls were randomly selected from birth certificate records. Interviews were conducted by telephone, using a structured questionnaire. Exposure estimates were based on women's self-reports of conditions in the residence and workplace. Eighty-three per cent of the mothers were white, and 66% were between 25 and 34 years old. After adjusting all results for known risk factors and confounding variables, we found no significant increased risk of CCM in subjects whose mothers reported being exposed during earl...Continue Reading

References

Mar 11, 1978·Lancet·P MillerT H Shepard
Jul 1, 1979·The Journal of Pediatrics·S K ClarrenN C Myrianthopoulos
Jan 1, 1992·International Archives of Occupational and Environmental Health·J Tikkanen, O P Heinonen
Aug 19, 1992·JAMA : the Journal of the American Medical Association·A MilunskyH Jick
Nov 1, 1991·European Journal of Epidemiology·J Tikkanen, O P Heinonen
Nov 1, 1990·American Journal of Obstetrics and Gynecology·M A KlebanoffJ C Carey
Jan 1, 1990·American Journal of Epidemiology·A M TeitelmanM B Bracken
Jan 1, 1985·American Journal of Epidemiology·C FerenczJ W Downing
Jun 1, 1985·American Journal of Epidemiology·J KlineD Warburton
Mar 1, 1984·American Journal of Epidemiology·N MamelleP Lazar
Jan 1, 1981·American Journal of Epidemiology·G S Berkowitz
May 1, 1995·European Heart Journal·E BuskensJ Hess
Oct 20, 1998·Journal of Occupational and Environmental Medicine·S LinL Dlugosz

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Citations

Jun 7, 2013·Human Reproduction·K Agay-ShayC Peretz
Oct 4, 2012·Environmental Health Perspectives·Alissa R Van ZutphenSyni-An Hwang
Jun 8, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Hao T DuongUNKNOWN National Birth Defects Prevention Study
Feb 24, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Tatiana Diehl ZenGiorgio Adriano Paskulin
May 26, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Audrey L FlakMary E Cogswell
Jan 11, 2014·Environmental Research·Alissa R Van ZutphenShao Lin
Feb 4, 2010·Air Medical Journal·Patricia Van Dyke
Aug 6, 2016·Environmental Health Perspectives·Nathalie AugerTom Kosatsky
Jul 29, 2006·International Journal of Circumpolar Health·Katriina Kukkonen-Harjula, Kyllikki Kauppinen
May 30, 2020·Journal of Developmental Origins of Health and Disease·Wayne R LawrenceShao Lin
Nov 6, 2020·BMJ : British Medical Journal·Matthew Francis ChersichUNKNOWN Climate Change and Heat-Health Study Group
Jun 3, 2021·International Journal of Environmental Research and Public Health·Marjan Mosalman Haghighi Climate Change And Heat-Health Study Group

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