PMID: 8967482May 1, 1996Paper

Physical fitness, muscle morphology, and insulin-stimulated limb blood flow in normal subjects

The American Journal of Physiology
T UtriainenH Yki-Järvinen

Abstract

The response of limb blood flow to insulin is highly variable even in normal subjects. We examined whether physical fitness or differences in muscle morphology contribute to this variation. Maximal aerobic power, muscle fiber composition and capillarization, and the response of forearm glucose extraction and blood flow to a sequential hyperinsulinemic euglycemic clamp (serum insulin 374 +/- 10, 816 +/- 23, and 2,768 +/- 78 pmol/l) were determined in 16 normal males (age 25 +/- 1 yr, body mass index 24 +/- 1 kg/m2). Maximal aerobic power correlated positively with the proportion of type I fibers (r = 0.67, P < 0.01) and negatively with the proportion of type IIb fibers (r = -0.73, P < 0.01). Fiber composition but not blood flow correlated significantly with forearm and whole body glucose uptake. All doses of insulin significantly increased forearm blood flow, maximally by 123 +/- 21%. The ratio of capillaries per fiber was significantly correlated with basal and insulin-stimulated blood flow (0.58- 0.76, P < 0.05-0.01). Mean arterial blood pressure and the insulin-induced increase in blood flow were inversely correlated (r = -0.59, P < 0.05). We conclude that variation in glucose extraction is significantly determined by muscle ...Continue Reading

Citations

Apr 26, 2008·Scandinavian Journal of Medicine & Science in Sports·H ShimadaK Ishiwata
Jun 19, 2001·American Journal of Physiology. Endocrinology and Metabolism·M J TothE T Poehlman
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michael G ClarkStephen Rattigan
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·K MatherA Baron
Aug 29, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Mary E J LottLawrence I Sinoway
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T S TsaoM J Charron

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