Physical Frailty and Cognitive Functioning in Depressed Older Adults: Findings From the NESDO Study

Journal of the American Medical Directors Association
Matheus ArtsR C Oude Voshaar

Abstract

Cognitive frailty has recently been defined as the co-occurrence of physical frailty and cognitive impairment. Late-life depression is associated with both physical frailty and cognitive impairment, especially processing speed and executive functioning. The objective of this study was to investigate the association between physical frailty and cognitive functioning in depressed older persons. Baseline data of a depressed cohort, participating in the Netherlands Study of Depression in Older persons (NESDO). Primary care and specialized mental health care. A total of 378 patients (≥60 years) with depression according to DSM-IV criteria and a MMSE score of 24 points or higher. The physical frailty phenotype as well as its individual criteria (weight loss, weakness, exhaustion, slowness, low activity). Cognitive functioning was examined in 4 domains: verbal memory, working memory, interference control, and processing speed. Of the 378 depressed patients (range 60-90 years; 66.1% women), 61 were classified as robust (no frailty criteria present), 214 as prefrail (1 or 2 frailty criteria present), and 103 as frail (≥3 criteria). Linear regression analyses, adjusted for confounders, showed that the severity of physical frailty was ass...Continue Reading

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May 29, 2016·Journal of the American Medical Directors Association·John E Morley
Aug 1, 2016·Journal of the American Medical Directors Association·John E Morley, Susan A Farr
Mar 2, 2017·Journal of the American Geriatrics Society·Catharine R GaleIan J Deary
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May 23, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Astrid LugtenburgRichard C Oude Voshaar
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Oct 6, 2020·The Journal of Trauma and Acute Care Surgery·Mina Faye NordnessJo Ellen Wilson
Nov 27, 2020·Frontiers in Medicine·Laura Lorenzo-LópezJosé Carlos Millán-Calenti
Dec 15, 2020·Aging & Mental Health·Marcus K BorgesRichard C Oude Voshaar
Apr 6, 2021·Current HIV/AIDS Reports·Kristine M Erlandson, Damani A Piggott

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