Physical linkage of the B29/Ig-beta (CD79B) gene to the skeletal muscle, sodium-channel, and growth hormone genes in rat and human

Genomics
S NakazatoM Ono

Abstract

In the region between the polyadenylation site of the rat skeletal muscle (SkM) Na-channel gene and the 5' end of the growth hormone (GH) gene, a gene coding for B-cell-specific membrane protein B29/Ig-beta was found and noted to have the same orientation as the Na-channel and GH genes. Rat B29/Ig-beta gene was 3.1 kb in length with six exons and was separated by 3.3 and 9.3 kb from Na-channel and GH genes, respectively. Rat B29/Ig-beta protein comprised 228 amino acids, and its amino acid sequence was 85 and 69% identical with the mouse and human counterparts, respectively. With the long-area PCR method, genomic DNA connecting human SkM Na-channel (SCN4A) and B29/Ig-beta (CD79B) genes and CD79B and GH (GH1) genes was amplified, and the physical linkage of SCN4A/CD79B/ GH1 genes in the human genome was established. The human CD79B gene was separated by 6.3 and 10.5 kb from the SCN4A and GH1 genes, respectively.

References

Jan 1, 1992·Annual Review of Immunology·M Reth
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G G HermansonR Wall
Jan 1, 1988·Annual Review of Biochemistry·D S Gross, W T Garrard
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G G HermansonR Wall
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S A Omori, R Wall
Dec 1, 1995·Molecular and Cellular Biology·B K JonesN E Cooke

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