PMID: 9647638Jul 1, 1998Paper

Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex

Genome Research
N TripodisJ Ragoussis

Abstract

We have physically mapped and cloned a 2.5-Mb chromosomal segment flanking the centromeric end of the major histocompatibility complex (MHC). We characterized in detail 27 YACs, 144 cosmids, 51 PACs, and 5 BACs, which will facilitate the complete genomic sequencing of this region of chromosome 6. The contig contains the genes encoding CSBP, p21, HSU09564 serine kinase, ZNF76, TCP-11, RPS10, HMGI(Y), BAK, and the human homolog of Tctex-7 (HSET). The GLO1 gene was mapped further centromeric in the 6p21.2-6p21.1 region toward TCTE-1. The gene order of the GLO1-HMGI(Y) segment in respect to the centromere is similar to the gene order in the mouse t-chromosome distal inversion, indicating that there is conservation in gene content but not gene order between humans and mice in this region. The close linkage of the BAK and CSBP genes to the MHC is of interest because of their possible involvement in autoimmune disease.

References

Nov 24, 1979·Nucleic Acids Research·H C Birnboim, J Doly
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A StrasserA W Harris
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z LarinH Lehrach
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H M AlbertsenD Cohen
Apr 1, 1989·Computer Applications in the Biosciences : CABIOS·J SulstonT Horsnell
Nov 11, 1995·Nucleic Acids Research·D Markie
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Dec 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D NizeticH Lehrach
Jun 1, 1993·British Journal of Cancer·M JohanssonS Heim
Nov 1, 1995·Genomics·M HeiskanenA Palotie
Nov 1, 1995·Genome Research·M G OlavesenJ Ragoussis
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A CoulsonJ Karn

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Citations

May 13, 1999·Immunological Reviews·S Beck, J Trowsdale
Mar 22, 2000·DNA Sequence : the Journal of DNA Sequencing and Mapping·C E HerbisonP Price
Oct 11, 2015·International Ophthalmology·Francesco PichiPiergiorgio Neri
Jul 21, 2000·Tissue Antigens·A FoissacA Cambon-Thomsen
Jul 29, 2004·The Journal of Biological Chemistry·Gang Zheng, Yu-Chung Yang
Mar 22, 2014·Biochemical Society Transactions·Alaa ShafieNaila Rabbani
Jul 14, 2016·Glycoconjugate Journal·Naila RabbaniPaul J Thornalley
May 21, 2011·The Tohoku Journal of Experimental Medicine·Yanyan LiuYongxin Ma
Jan 6, 2021·International Journal of Molecular Sciences·Silvia YumnamSun Yeou Kim
Jan 30, 2002·Molecular and Biochemical Parasitology·Kirsten CrossgroveClaude V Maina
May 29, 1998·Gene·J A HerbergJ Trowsdale

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