PMID: 8613150Jan 1, 1996Paper

Physical mapping of the E/C and grc regions of the rat major histocompatibility complex

Immunogenetics
X J YuanT J Gill

Abstract

Alignment of class I-hybridizing cosmids from an R21 (AlBlDlEugrc+) genomic DNA library gave two contigs: one [150 kilobases (kb)] encompassed the E/C region, or a large part thereof, and the other (110 kb) contained the grc region which has genes influencing resistance to chemical carcinogens (rcc), fertility (ft), and growth (dw-3). Amplification of gene sequences in the four cosmids in the E/C region using Eu-specific and LW2 (RT1.C)-specific primers showed that each cosmid contained both Eu-like and C-like genes. They are clearly different but closely associated, and they show some variation from the prototypic E (Eu) and C (LW2) genes, respectively. Comparison of DNA from grc+ and grc- strains of rats showed that the deletion in the grc- strains was approximately 50 kb, and that it was located on two of the three cosmids in the grc-region contig. The use of specific class I probes showed that the grc region contained tandemly duplicated RT1.O-RT1.N genes and that the RT.BM1 loci lay outside of the grc region. Neither contig reacted with probes specific for class II, TNFA, Hsp70, or RT1.M genes. The data presented here and the previous data in the literature (summarized in Gill et al. 1995) suggest that the gene order in th...Continue Reading

References

Jan 1, 1992·Immunogenetics·D VardimonT J Gill
Jan 1, 1989·Immunogenetics·H W KunzT J Gill
Jan 1, 1989·Immunogenetics·A RadojcicT J Gill
Apr 1, 1986·Analytical Biochemistry·E C StraussL E Hood
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C Hunt, R I Morimoto
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A PoustkaH Lehrach
Jan 1, 1994·Immunogenetics·L WalterE Günther
Jan 1, 1995·Immunogenetics·D LambrachtK Wonigeit
Jan 1, 1995·Immunogenetics·C R WangK F Lindahl
Jan 1, 1994·Immunogenetics·M J KirisitsT J Gill
Jan 1, 1994·Immunogenetics·M J KirisitsT J Gill
Jan 1, 1994·Immunogenetics·S K SalgarT J Gill
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M F MelhemT J Gill
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C R Wang, K F Lindahl
Jun 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J J RushtonT J Gill

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Citations

May 20, 1999·Transplantation Proceedings·X J YuanT J Gill
May 20, 1999·Transplantation Proceedings·X J YuanT J Gill
Jun 1, 1997·American Journal of Reproductive Immunology : AJRI·T J GillH W Kunz
Mar 31, 1999·American Journal of Reproductive Immunology : AJRI·T J Gill
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S IoanniduE Günther

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