Physical mechanical and tablet formation properties of hydroxypropylcellulose: in pure form and in mixtures

AAPS PharmSciTech
K M Picker-Freyer, Thomas Durig

Abstract

The aim of the study was to analyze hydroxypropylcellulose (HPC) in pure form and in excipient mixtures and to relate its physical and chemical properties to tablet binder functionality. The materials used were Klucel hydroxypropylcellulose grades ranging from low to high molecular weight (80-1000 kDa) of regular particle size (250 microm mean size) and fine particle size (80 microm mean size). These were compared with microcrystalline cellulose, spray-dried lactose, and dicalcium phosphate dihydrate. Thermal behavior of HPC was analyzed by modulated temperature differential scanning calorimetry (MTDSC). Tablets of the pure materials and of dry blends with 4% low viscosity, fine particle HPC and 30% high viscosity, fine particle HPC were produced on an instrumented eccentric tableting machine at 3 relative humidities. The 3-dimensional (3-D) model with the parameters time plasticity d, pressure plasticity e, and the twisting angle omega, the inverse of fast elastic decompression was compared with the Heckel method for characterization of compaction. Elastic recovery and compactibility were also studied. The results show that HPC tablet formation is characterized by high plastic deformation. The d, e, and omega values were marke...Continue Reading

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Citations

Sep 11, 2012·AAPS PharmSciTech·Noorullah Naqvi MohammedMichael A Repka
Nov 12, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Giulia LoretiLucia Zema
Jul 2, 2009·Drug Development and Industrial Pharmacy·Rishi KapilSanju Dhawan
Jun 11, 2015·Journal of Pharmaceutical Sciences·Frederick Osei-Yeboah, Changquan Calvin Sun
Apr 19, 2011·International Journal of Pharmaceutics·Sameh Abdel-Hamid, Gabriele Betz
Nov 8, 2014·AAPS PharmSciTech·Arti BanerjeeSubhash Gore
Jul 18, 2009·AAPS PharmSciTech·Cynthia K BrownUNKNOWN International Pharmaceutical Federation
Oct 18, 2016·The Journal of Pharmacy and Pharmacology·Matthew R WilsonGavin P Andrews
Jan 9, 2021·Expert Opinion on Drug Delivery·Prashantkumar K ParmarArvind K Bansal
Oct 19, 2020·International Journal of Pharmaceutics·Guluzar Gorkem BuyukgozRajesh N Davé
Jan 8, 2021·International Journal of Pharmaceutics: X·Christian LuebbertGabriele Sadowski
Apr 9, 2021·Advanced Drug Delivery Reviews·Sedigheh BorandehJukka Seppälä
Aug 7, 2021·International Journal of Pharmaceutics·Cedrine de BackereValérie Vanhoorne
Jun 6, 2018·Biomacromolecules·Hale Cigdem ArcaKevin J Edgar
Feb 14, 2020·Biomacromolecules·Christopher M WaltersMark J MacLachlan

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