Physical modeling of cell geometric order in an epithelial tissue

Proceedings of the National Academy of Sciences of the United States of America
Sascha HilgenfeldtRichard W Carthew

Abstract

In multicellular organisms, cells pack together to form tissues of intricate and well defined morphology. How such cell-packing geometries arise is an important open question in biology, because the functionality of many differentiated tissues depends on their reliable formation. We show that combining adhesive forces due to E- and N-cadherin with a quantitative description of cell membrane elasticity in an interfacial energy model explains not only the qualitative neighbor relations, but also the detailed geometry of a tissue. The characteristic cellular geometries in the eyes of both wild-type Drosophila and genetic mutants are accurately reproduced by using a fixed set of few, physically motivated parameters. The model predicts adhesion strengths in the eye epithelium, quantifies their role relative to membrane elasticity, and reveals how simple minimization of interfacial energy can give rise to complex geometric patterns of important biological functionality.

References

Dec 1, 1989·Developmental Biology·R L Cagan, D F Ready
May 14, 1999·Trends in Genetics : TIG·B J Thomas, D A Wassarman
Dec 10, 1999·Biophysical Journal·J Dai, M P Sheetz
Apr 11, 2000·Molecular and Cellular Biology·Y TakatsuN Ueno
Apr 27, 2004·Experimental Eye Research·J R KuszakC Sivertson
Mar 1, 1996·Trends in Cell Biology·M P Sheetz, J Dai
Oct 8, 2004·Nature·Takashi Hayashi, Richard W Carthew
Jan 15, 2005·Developmental Biology·Ramsey A Foty, Malcolm S Steinberg
Jan 18, 2005·Trends in Cell Biology·Thomas Lecuit
Jun 21, 2005·Current Opinion in Genetics & Development·Richard W Carthew
Aug 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aljoscha NernS Lawrence Zipursky
Jan 20, 2007·Science·Daisuke MizunoF C Mackintosh
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jos KäferFrançois Graner
May 1, 1997·Development Genes and Evolution·J Westin, M Lardelli

❮ Previous
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Citations

Aug 3, 2012·Biomechanics and Modeling in Mechanobiology·Sagar D Joshi, Lance A Davidson
Aug 19, 2011·Nature Reviews. Cancer·Franziska MichorJonathan Widom
Jun 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lea-Laetitia PontaniJasna Brujic
Oct 23, 2013·The Journal of Cell Biology·Benedetta CerrutiAndrea Gamba
Apr 26, 2013·Journal of the Royal Society, Interface·Brian N Cox
Nov 18, 2010·The European Physical Journal. E, Soft Matter·D B StapleF Jülicher
May 25, 2011·The European Physical Journal. E, Soft Matter·M P Miklius, S Hilgenfeldt
Apr 26, 2013·The European Physical Journal. E, Soft Matter·S IshiharaF Graner
May 1, 2009·Development·Nicole GorfinkielAlfonso Martinez Arias
Apr 17, 2012·Journal of Cell Science·Hamid TabdiliDeborah E Leckband
Jun 22, 2012·Journal of Cell Science·Hamid TabdiliDeborah Leckband
Jul 10, 2010·PLoS Computational Biology·David E LarsonRoss L Cagan
Aug 5, 2011·PLoS Computational Biology·Ian M GempSascha Hilgenfeldt
Sep 1, 2012·PLoS Computational Biology·Guillaume SalbreuxDavid K Lubensky
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Edouard HannezoJean-Francois Joanny
Jul 12, 2011·Annual Review of Cell and Developmental Biology·Thomas LecuitEdwin Munro
Dec 25, 2015·The European Physical Journal. E, Soft Matter·Marc Durand
Aug 12, 2009·Seminars in Cell & Developmental Biology·Ana M MateusAlfonso Martinez Arias
Oct 28, 2015·The Journal of Cell Biology·Evan Heller, Elaine Fuchs
Dec 17, 2014·Developmental Biology·Joseph H Shawky, Lance A Davidson
May 5, 2009·Nature Methods·Guy B BlanchardRichard J Adams
Sep 22, 2015·Nature Cell Biology·Claudio CollinetThomas Lecuit
Jun 5, 2014·Biophysical Journal·Alexander G FletcherStanislav Y Shvartsman
Feb 28, 2008·Current Biology : CB·Rodrigo Fernandez-Gonzalez, Jennifer A Zallen
May 28, 2013·Developmental Cell·Pierre-Luc BardetYohanns Bellaïche
Jul 31, 2012·Developmental Biology·Guangliang WangJeffrey D Amack
Aug 3, 2016·Seminars in Cell & Developmental Biology·Jessica C Yu, Rodrigo Fernandez-Gonzalez
Mar 27, 2012·Stem Cells International·Kevin S TieuMary E Sehl
Aug 9, 2016·Seminars in Cell & Developmental Biology·Matthias Merkel, M Lisa Manning
Apr 9, 2017·Biomechanics and Modeling in Mechanobiology·A R B BoydP V S Lee
Mar 2, 2017·International Journal for Numerical Methods in Biomedical Engineering·Ismael González-Valverde, José Manuel García-Aznar
Oct 11, 2017·Mathematical Medicine and Biology : a Journal of the IMA·Alexander Nestor-BergmannOliver E Jensen
May 28, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Haibo BaiRobert A Anders
Dec 1, 2017·Development·François Graner, Daniel Riveline
Jan 10, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Yuandi WangNanjun Yan
Jul 9, 2009·Nature Reviews. Genetics·Andrew C OatesCarl-Philipp Heisenberg
Apr 3, 2019·Physical Review. E·Pierre A Haas, Raymond E Goldstein

❮ Previous
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