Physical models for exploring DNA topology.

Journal of Biomolecular Structure & Dynamics
N C Seeman

Abstract

Two types of physical models have been developed for treating DNA molecules whose topology is of interest. The two model motifs combine jacks-and-straws molecular representations with flexible tubing in different proportions. Both motifs present a low-resolution construct of DNA that retains helix axes, strand individuality and the distinguishability of the major and minor grooves. Molecules whose double helix axes are branched are modelled by stiff double helices and flexible branch sites. Supercoiled and knotted DNA molecules are modelled on a smaller scale, in a system in which a flexible backbone is supported by a series of stiff helical struts; removal of this scaffolding immediately reveals the linking of the strands. The models are light and easy to construct. They may be used either for demonstrations or as a research tool that assists the interpretation data.

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Citations

May 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Banani ChakrabortyNadrian C Seeman
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E MuellerN C Seeman
Dec 1, 1990·Journal of Biomolecular Structure & Dynamics·N C Seeman
Apr 1, 1991·Journal of Biomolecular Structure & Dynamics·G Benedetti, S Morosetti
Apr 1, 1993·Journal of Biomolecular Structure & Dynamics·H WangN C Seeman
Sep 15, 2015·ACS Nano·Yoel P OhayonNadrian C Seeman
Apr 25, 2006·Journal of Molecular Graphics & Modelling·Jeffrey J BiracNadrian C Seeman
Apr 4, 2006·Biophysical Journal·William B Sherman, Nadrian C Seeman
Sep 12, 2000·Chemistry & Biology·R ShaN C Seeman
Dec 28, 1999·Journal of Molecular Biology·W SunN C Seeman
Nov 17, 1992·Biochemistry·S M DuN C Seeman
Apr 6, 1993·Biochemistry·T J Fu, N C Seeman
Jan 24, 1995·Biochemistry·H Wang, N C Seeman
Sep 1, 1988·Biopolymers·M L PetrilloN C Seeman
May 1, 1989·Electrophoresis·N C SeemanN R Kallenbach
Sep 1, 1991·DNA and Cell Biology·N C Seeman
Apr 11, 2012·Journal of Computational Chemistry·William B Sherman
Jun 11, 2008·Nano Letters·Mudalige Thilak KumaraWilliam B Sherman
May 27, 2004·Journal of the American Chemical Society·Phiset Sa-ArdyenNadrian C Seeman
Apr 11, 1997·Journal of Molecular Biology·H QiuN C Seeman

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