Physical morbidity by surgical approach and tumor location in skull base surgery

Head & Neck
John R de AlmeidaAllan Vescan

Abstract

Skull base tumors are associated with physical symptoms that vary depending on location and surgical approach. Skull base surgery patients (n = 138) were retrospectively reviewed and physical symptoms were quantified. Patients were divided into 4 groups by surgical approach (open, endoscopic) and tumor location (anterior, central). Multivariate analyses determined odds for symptom development. Patients with anterior lesions presented with more nasal symptoms compared to those with central lesions (63% vs 6.8%; p < .001). Those with central lesions presented with more neurologic (41.1% vs 12.3%; p < .001) and endocrine symptoms (19.2% vs 0%; p < .001). Three of 4 groups experienced a reduction in neurologic and visual symptoms after surgery. One group (endoscopic/central) experienced a reduction in endocrine and an increase in nasal symptoms. Anterior tumors (p = .02) and endoscopic approaches (p = .002) predicted increased nasal morbidity. Physical morbidity from skull base tumors may vary based on tumor location and surgical approach.

References

Jul 1, 1997·Journal of Neurosurgery·H D Jho, R L Carrau
Dec 21, 2002·Minimally Invasive Neurosurgery : MIN·P CappabiancaE de Divitiis
Dec 17, 2003·Archives of Otolaryngology--head & Neck Surgery·Ziv GilDan M Fliss
Mar 24, 2004·Journal of Neurosurgery·Giulio MairaAndrea Vignati
May 13, 2004·Journal of Neurosurgery·Ziv GilDan M Fliss
Nov 17, 2004·Archives of Otolaryngology--head & Neck Surgery·Ziv GilDan M Fliss
May 21, 2005·Minimally Invasive Neurosurgery : MIN·A RudnikI Duda
May 28, 2005·Neurosurgery·Pietro MortiniMassimo Giovanelli
Jun 2, 2005·Journal of Neurosurgery·Edward R LawsAaron S Dumont
Jun 2, 2005·Journal of Neurosurgery·Joshua R DusickNeil A Martin
Jun 27, 2006·American Journal of Otolaryngology·Emily F Rudnick, Laurence J DiNardo
Aug 5, 2006·Neurosurgery·Giorgio FrankFabio Calbucci
Aug 7, 2007·British Journal of Neurosurgery·A K JainJ R Bapuraj
Sep 5, 2007·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Chris WoertgenJürgen Strutz
Apr 29, 2008·The Laryngoscope·Aldo C StammDiego R Herman
Jul 24, 2008·Neurological Research·Yazhuo ZhangMingxue Piao
Nov 28, 2008·Neurosurgical Focus·Giorgio CarrabbaFred Gentili
Jan 31, 2009·American Journal of Rhinology·Thomas S HigginsJoseph K Han
Dec 8, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Madeleine R SchabergWilliam Cobb
May 11, 2010·Acta neurochirurgica·Neil L Dorward
Jul 2, 2010·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Jatin P Shah
Jul 2, 2010·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Ziv Gil, Dan M Fliss
Jul 2, 2010·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Abraham AbergelZiv Gil
Jul 2, 2010·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Harshita PantAmin B Kassam
Sep 9, 2010·Head & Neck·John R de AlmeidaAllan D Vescan

❮ Previous
Next ❯

Citations

Mar 29, 2014·Acta Oto-laryngologica·Magis MandapathilJochen A Werner
Feb 25, 2014·British Journal of Neurosurgery·Mathew Joseph GallagherNijaguna Mathad
Jan 27, 2015·Clinical Neurology and Neurosurgery·Ahmed J AwadManish K Aghi
Oct 7, 2017·International Forum of Allergy & Rhinology·Christopher R RoxburyDouglas D Reh
Jul 23, 2019·International Forum of Allergy & Rhinology·Eric W WangCarl H Snyderman
Dec 14, 2019·Acta neurochirurgica·Lorenzo GiammatteiRoy T Daniel
Jan 5, 2020·Journal of Neuro-oncology·Christopher W Noel, John R de Almeida
Sep 9, 2016·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Soroush LarjaniJohn R de Almeida

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.