PMID: 6399750Jan 1, 1984Paper

Physical properties of cholesteryl esters

Progress in Lipid Research
G S GinsburgD M Small

Abstract

Cholesteryl esters, the intracellular storage form and intravascular transport form of cholesterol, can exist in crystal, liquid crystal and liquid states. The physical state of cholesteryl esters at physiologic temperatures may be a determinant of their pathogenicity. This review has surveyed saturated aliphatic cholesteryl esters of chain length 1 to 24 carbons and a series of medium-chained unsaturated cholesteryl esters from chain lengths 14 to 24 carbons. A systematic study of transition temperatures by polarizing microscopy and enthalpies by differential scanning calorimetry has provided unifying concepts concerning the phase behavior as a function of chain length and unsaturation. Neat cholesteryl esters show chain-length dependence of transition temperature and enthalpy of both the crystal and liquid crystal transitions. Double bond position along the fatty acyl chain affected stability of the liquid crystal phases; a smectic phase was not observed for any cholesteryl ester with a double bond more proximal than delta 9. 13C NMR spectroscopy in the isotropic liquid phase has provided evidence suggesting a balance of ring-ring vs. chain-chain interactions as a determinant for isotropic liquid----cholesteric vs. isotropic ...Continue Reading

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Citations

Aug 13, 2005·Lipids·Andrea Coronado-Gray, Rik van Antwerpen
Apr 4, 2003·International Journal of Pharmaceutics·Fars AlanaziD Robert Lu
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D L Dorset, W A Pangborn
Oct 7, 2008·Journal of Lipid Research·Igor A Butovich
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Julia J HwangSamuel I Stupp
Sep 17, 2010·Journal of Pharmaceutical Sciences·Rabkwan ChuealeeTeerapol Srichana
Jul 14, 2010·Journal of Colloid and Interface Science·Judith KuntscheHeike Bunjes
Aug 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Judith KuntscheHeike Bunjes
Jun 23, 2005·The Journal of Pharmacy and Pharmacology·Heike Bunjes, Thomas Rades
Jun 23, 2015·Biomacromolecules·Francesca ErcoleThomas P Davis
Oct 12, 2013·The Ocular Surface·P Ewen King-SmithRichard J Braun
Jan 10, 2006·Biophysical Journal·Mikko HeikeläMarja T Hyvönen
May 22, 2019·Investigative Ophthalmology & Visual Science·Douglas BorchmanGary N Foulks
Sep 13, 2019·Journal of Lipid Research·Sarah E HancockTodd W Mitchell
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eva DaelsBart Goderis
Jan 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amber WilkersonIgor Butovich
Feb 10, 2021·International Journal of Molecular Sciences·Igor A ButovichSeher Yuksel
Jan 25, 2020·Chemistry and Physics of Lipids·Mary R StarichNico Tjandra
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Sep 17, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Pinchu XavierPadmanabhan Viswanath

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