Physical properties of rabbit articular cartilage after transection of the anterior cruciate ligament

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
R L SahR D Coutts

Abstract

The effect of unilateral transection of the anterior cruciate ligament on the confined compression and swelling properties of the distal femoral articular cartilage of skeletally mature rabbits at 9 weeks after surgery was determined. Gross morphological grading of the transected and contralateral control distal femora stained with India ink confirmed that cartilage degeneration had been induced by ligament transection. Osteochondral cores, 1.8 mm in diameter, were harvested from the medial femoral condyles. The modulus, permeability, and electrokinetic (streaming potential) coefficient of the articular cartilage of the osteochondral cores were assessed by confined compression creep experiments. The properties (mean +/- SD) of control cartilage were: confined compression modulus, 0.75 +/- 0.28 MPa; hydraulic permeability, 0.63 +/- 0.28 x 10(-15) m2/Pa*sec; and electrokinetic coefficient, 0.16 +/- 0.31 x 10(-9) V/Pa. In transected knees, the modulus was reduced by 18% (p = 0.04), while the permeability and electrokinetic coefficient were not detectably altered. The change in modulus was accompanied by a trend (p = 0.07) toward a decrease (-11%) in the glycosaminoglycan density within the tissue, a significant increase (p < 0.001...Continue Reading

References

May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K A AthanasiouV C Mow
Feb 1, 1990·Seminars in Arthritis and Rheumatism·R D Altman, D D Dean
Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S AkizukiD S Howell
Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E H FrankD R Eyre
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S L CarneyJ D Sandy
Jul 1, 1973·Annals of the Rheumatic Diseases·M J Pond, G Nuki
Sep 21, 1968·Nature·A Maroudas, P Bullough
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S L CarneyJ D Sandy
Jan 1, 1983·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D H HochD R Eyre
Nov 1, 1981·Journal of Biomechanical Engineering·R C LeeD K Roylance
Feb 1, 1980·Journal of Biomechanical Engineering·V C MowC G Armstrong
Sep 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E S ReindelR L Sah
Jul 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L A SettonD S Howell
Feb 1, 1995·Arthritis and Rheumatism·L J BonassarA J Grodzinsky
Jun 1, 1994·Annals of the Rheumatic Diseases·K P Pritzker
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L A SettonD S Howell
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F GuilakV C Mow
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F J MüllerJ C Pita
Jan 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R L SahA J Grodzinsky
Jun 1, 1996·Osteoarthritis and Cartilage·M YoshiokaS A Hacker

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Citations

Mar 1, 2006·Biomechanics and Modeling in Mechanobiology·Rami K KorhonenJukka S Jurvelin
Jun 21, 2001·Clinical Biomechanics·M.Z. BendjaballahD.J. Zukor
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marie-Pierre Hellio Le GraverandDavid A Hart
Dec 21, 2004·Annals of the Rheumatic Diseases·A R ShikhmanM K Lotz
Oct 2, 2008·Arthritis Research & Therapy·Masaya HayashiIchiro Sekiya
Feb 5, 2008·The Journal of Bone and Joint Surgery. American Volume·Todd O McKinleyThomas D Brown
May 20, 2006·Biomechanics and Modeling in Mechanobiology·W WilsonC C van Donkelaar
Mar 20, 2013·Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine·Pascal EdouardEmmanuel Coudeyre
Sep 29, 2011·Journal of Biomechanics·William J McCartyRobert L Sah
Jun 11, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yasushi OshimaDavid Amiel
Jul 15, 2015·Journal of Biomechanics·J T A MäkeläR K Korhonen
Dec 6, 2008·Magnetic Resonance Imaging·Jesus LozanoC Benjamin Ma
Dec 19, 2006·Journal of Biomechanics·Anneliese D HeinerYuki Tochigi
Aug 20, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shinya FujitaToshikazu Kubo
May 21, 2013·Arthritis and Rheumatism·Hiroyuki NakaharaHiroshi Asahara
Sep 3, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shuji NakagawaToshikazu Kubo
Sep 20, 2005·Journal of Biomechanics·Maria L RoemhildtBruce D Beynnon

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