PMID: 2492609Mar 1, 1989Paper

Physical properties of the Creutzfeldt-Jakob disease agent

Journal of Virology
T K SklaviadisE E Manuelidis

Abstract

In this report, we present the first physical characterization of the Creutzfeld-Jakob disease agent. Preparations with high yields of infectivity (assayed infectious units) were obtained by a novel, gentle procedure in which initially sedimenting Gp34 ("prion" protein) was disaggregated by a variety of criteria with no subsequent loss of infectivity. Studies with this preparation indicate that most of the Creutzfeld-Jakob disease agent has both a viruslike size and density. In velocity sedimentation and isopycnic sucrose gradients, infectivity comigrated with nucleic acid-protein complexes of appreciable size.

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Citations

Jun 14, 1991·Science·S B Prusiner
Aug 22, 1991·Nature·C Weissmann
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