Physical rehabilitation and risk of atherosclerosis after successful kidney transplantation

Transplantation Proceedings
J JuskowaJ Sierdziński

Abstract

Regular physical activity is usually associated with significant health benefits, but therapeutic exercise is seldom routine in renal transplant recipients. We report a randomized clinical trial of exercise training after renal transplantation. Sixty-nine patients were randomly recruited on the first or second day after kidney transplantation into two groups: exercise intervention (PT) and standard care (CT) as controls. The exercise training program consisted of tailored exercises to be performed under a physiotherapist's supervision for 15 to 30 minutes every second hospital day. At that time, biochemical markers of graft function were assessed including specific tests for atherosclerosis. Repeated measures analysis of variance was performed to determine differences between the two groups. We found an inverse correlation between total homocysteine as well as interleukin-18 (IL:18) levels and muscle strength of the upper limbs (r = -.78, P < .0001). There was a positive correlation between muscle strength and improved graft function in the PT group versus CT groups (r = .05; P < .05). Hyperhomocysteinemia and high IL-18 expression in renal allograft recipients may be independent markers of early atherosclerosis development.

References

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Citations

Jun 4, 2013·Transplantation Proceedings·L RicaurteUNKNOWN Organ Transplant Group
Jan 13, 2015·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Vladimír TeplanMilena Štollová
Aug 24, 2016·American Journal of Physical Medicine & Rehabilitation·Jill NealeNicolette C Bishop
Aug 24, 2012·World Journal of Transplantation·Giulio RomanoDomenico Montanaro
Jan 7, 2017·World Journal of Transplantation·Tania Janaudis-FerreiraCecile Beaurepaire
May 6, 2015·The Cochrane Database of Systematic Reviews·Amy KangMeg J Jardine
Oct 7, 2011·The Cochrane Database of Systematic Reviews·Susanne Heiwe, Stefan H Jacobson
Jan 17, 2019·Journal of Nephrology·Patrizia CalellaVincenzo Bellizzi
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Jun 15, 2018·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Caixia LiHuijuan Lu
Sep 1, 2018·Clinical and Experimental Nephrology·Hideyo OguchiTadashi Sofue
Dec 2, 2020·Renal Failure·Lucia MasieroGiovanni Mosconi
Feb 21, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Tania Janaudis-FerreiraJill Boruff
Mar 19, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Alexandra KastelzEnrico Benedetti
May 14, 2021·Clinical Kidney Journal·Stefan De Smet, Amaryllis H Van Craenenbroeck

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