PMID: 6107247Jan 1, 1980Paper

Physical training under the influence of beta-blockade in rats. III. Effects on muscular metabolism

European Journal of Applied Physiology and Occupational Physiology
M N Harri

Abstract

Rats were trained by daily running exercises for 7 weeks. In addition, one group of rats was trained under the influence of propranolol, while another group received daily injections of propranolol only. None of the treatments used had influence on the activities of myocardial enzymes: 3-hydroxyacyl-CoA - dehydrogenase (HADH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), and citrate synthase (CS) which were assayed for estimating oxidative capacity, or lactate dehydrogenase (LDH) which was used as a measure of anaerobic capacity. Training without propranolol resulted in elevated activities of the oxidative enzymes in M. extensor digitorum and in M. soleus. The corresponding changes in the rat group trained with propranolol always were much smaller, despite an equal amount of training. Only the trend for lowered activity of LDH was observable in skeletal muscle of the rat groups trained both with and without propranolol. Long-term beta-blockade alone did not induce enzymatic changes. It is concluded that a functioning sympathetic nervous system is necessary for the adaptive responses of muscular metabolism to training. Blockade of the sympathetic influence during exercise periods also hampers the training-induced r...Continue Reading

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Citations

Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·R J FavierR Flandrois
Jan 1, 1982·European Journal of Applied Physiology and Occupational Physiology·S MasumuraY Watanabe
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·D P ThomasR R Jenkins
Nov 1, 1984·Journal of the American College of Cardiology·W R HiattL D Horwitz
May 1, 1982·Acta Physiologica Scandinavica·M HarriR Oksanen-Rossi
Jan 1, 1984·Acta Physiologica Scandinavica·J SvedenhagK Asano
Feb 1, 1986·Acta Physiologica Scandinavica·M Harri, P Kuusela
Feb 23, 2012·American Journal of Physiology. Endocrinology and Metabolism·Rebecca Berdeaux, Randi Stewart
Jul 11, 1984·The American Journal of Physiology·J C Lawrence, W J Salsgiver
Nov 16, 2002·Journal of Applied Physiology·Iwona B ŁapoBogdan Sadowski
Sep 1, 1984·The American Journal of Physiology·J SvedenhagA Juhlin-Dannfelt

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