Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

Biomaterials Science
Thai Minh Duy LeDoo Sung Lee

Abstract

A dual pH- and temperature-responsive physically crosslinked and injectable hydrogel system was developed for efficient and long-term delivery of oncolytic adenoviruses (Ads). Three different types of physically crosslinked hydrogels with different chemical compositions and properties were prepared. These hydrogels with good biocompatibility can be injected at pH 9.0 and room temperature and rapidly form a gel under body or tumor microenvironment conditions. Ads encapsulated in hydrogels were released gradually without burst release. Moreover, these physically crosslinked hydrogels provided a protective environment for Ads and maintained their bioactivity for a long period of time. Compared to naked Ads, Ads protected by these physically crosslinked hydrogels showed strong cytotoxicity to cancer cells even after 11 days. The Ad-loaded hydrogel system also exhibited enhanced and long-term antitumor therapeutic effects in human xenograft tumor models. Due to these outstanding properties, Ad-loaded injectable hydrogels might have potential for long-term cancer treatment.

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Citations

Oct 8, 2020·Biomaterials Science·Kübra Kaygisiz, Christopher V Synatschke
Oct 20, 2020·Advanced Healthcare Materials·Fabio Rizzo, Nermin Seda Kehr
Oct 16, 2020·International Journal of Pharmaceutics·Yu-Cheng ZhouPei-Yang Hu
Dec 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi LiDoo Sung Lee
Feb 25, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dayananda KasalaChae-Ok Yun
Mar 7, 2021·Polymers·Jose Maria AlonsoVirginia Saez-Martinez

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Methods Mentioned

BETA
xenograft
infrared spectroscopy
flow cytometry
xenografts
SMA
fluorescence
fluorescence-activated cell sorting
FACS

Software Mentioned

[UNK]
ABi
SPSS
ABi 7500

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