Apr 1, 1976

Physico-chemical and immunological properties of acid alpha-glucosidase from various human tissues in relation to glycogenosis type II (Pompe's disease)

Clinica Chimica Acta; International Journal of Clinical Chemistry
J F KosterC J Lucas

Abstract

The physico-chemical and immunological properties of acid alpha-glucosidase from various human tissues have been studied. Heat stability of acid alpha-glucosidase from heart, liver and skeletal muscle is identical, but for kidney some different results are obtained. Identical isoelectrofocussing patterns are found for heart, liver and skeletal muscle. Furthermore, the effect of antiserum against human liver acid alpha-glucosidase on the activity of acid alpha-glucosidase from various tissues is studied. The results are discussed in relation to glycogenosis type II (Pompe's disease).

Mentioned in this Paper

Glucan 1,4-alpha-Glucosidase
Tissue Specificity
Immune Sera
Hot Temperature
Myocardium
Kidney
Glycogen Storage Disease Type II
Antigen-Antibody Reactions
Muscle
Isoelectric Focusing

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