Physico-chemical characteristics of gamma-irradiated gelatin

Progress in Biomaterials
Md Minhajul IslamM Fizur Rahman

Abstract

This article reports the effects of gamma irradiation (dose ranges 0.1-10 kGy from 60Co source) on the characteristics of solid gelatin and the physico-mechanical, microstructural and bioactive properties of the scaffold prepared from irradiated gelatin solution. FTIR, intrinsic viscosity, bloom strength, thermal properties, SEM, tensile properties, water uptake ability and antimicrobial activities of non-irradiated and irradiated solid gelatin and its scaffolds were investigated. The detailed experimental results for the solid gelatin demonstrated that 1 kGy γ-irradiated samples showed higher intrinsic viscosity, enhanced thermal stability and bloom strength than other irradiated samples. Furthermore, the scaffold thus prepared from irradiated and non-irradiated gelatin also revealed that 1 kGy samples showed the highest tensile strength and modulus with good water resistivity than other irradiated and non-irradiated samples. In addition to the physico-mechanical properties, 1 kGy scaffolds have also exhibited the highest resistivity towards microbial growth that can have potentiality as scaffold in biomedical sector. The enhanced functional and bioactive properties at low irradiation doses (1 kGy) may occurred due to an initi...Continue Reading

References

Jul 1, 1997·International Journal of Radiation Biology·A Filali-MouhimM Le Maire
Jul 14, 1999·Biomaterials·H W KangY Ikada
Jul 21, 2005·Journal of Biomaterials Science. Polymer Edition·Masahiko BesshoMasayuki Hara
Nov 9, 2006·Advances in Biochemical Engineering/biotechnology·James Velema, David Kaplan

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Citations

Jun 9, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Samia Mohamed OmarTamer M Sakr
Sep 23, 2018·Nanomaterials·Wan Hafizi Wan IshakMohd Cairul Iqbal Mohd Amin

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