PMID: 8966310Sep 1, 1996Paper

Physico-chemical characteristics of meglumine antimoniate in different storage conditions

Revista Da Sociedade Brasileira De Medicina Tropical
Gustavo A S RomeroP D Marsden

Abstract

During the period October 1992 to July 1995 we measured the osmolarity and pH of ampoules of meglumine antimoniate (glucantime) from lot 9206L-004 (manufactured by Rhodia Farma Ltd, of São Paulo, SP, Brazil) maintained in three temperature conditions namely 4 degrees C, 37 degrees C and ambiental. Although we observed statistically significant differences in osmolarity between samples, the limited number of measurements and the variation of this property in ampoules maintained at the same temperature were obstacles to obtain definitive conclusions. Such a variation was not found with pH. Assuming these parameters could reflect structural changes in the pentavalent antimony molecule, clearly further better controlled experiments are indicated.

References

Jun 1, 1985·Antimicrobial Agents and Chemotherapy·J D BermanB D Hanson
Jul 1, 1985·The American Journal of Tropical Medicine and Hygiene·J D ChulayM Mugambi
Apr 1, 1986·Revista Da Sociedade Brasileira De Medicina Tropical·P D Marsden
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R A GasserJ D Berman
Jul 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·N C HepburnP C Hayes
May 1, 1995·The American Journal of Tropical Medicine and Hygiene·M A FrancoJ G Dorea
Nov 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·N C Hepburn

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Citations

Apr 22, 2015·The American Journal of Tropical Medicine and Hygiene·Harparkash KaurSimon L Croft
Apr 22, 2008·Memórias do Instituto Oswaldo Cruz·Lúcio Mendes CabralTerezsa Cristina Dos Santos

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